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Drug info
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
Cystone
®
(TABLET)
The natural choice in urinary calculi & UTI
Introduction
Cystone tablet, a phytopharmaceutical
formulation, is recommended for
the comprehensive management
of urolithiasis and urinary tract
infections (UTIs). Cystone tablet
expels kidney stones and ureteric
stones and prevents their recurrence.
Cystone tablet is safe and effective
in the management of pediatric
urolithiasis and UTI, and causes
significant reduction of associated
symptoms.
Composition
Each Cystone tablet contains:
Exts.
Shilapushpa
(
Didymocarpus pedicellata
)
130 mg
Pashanabheda
(
Saxifaga ligulata
)
98 mg
Manjishtha (
Rubia cordifolia
) 32 mg
Nagaramusta
(
Cyperus scariosus
)
32 mg
Apamarga
(
Achyranthes aspera
)
32 mg
Gojiha (
Onosma bracteatum
) 32 mg
Sahadevi (
Vernonia cinerea
)
32 mg
Pdrs.
Hajrul yahood bhasma
32 mg
Shilajeet
26 mg
Processed in Vanatulasi (
Ocimum
basilicum
), Gokshura (
Tribulus
terrestris
), Lajjalu (
Mimosa pudica
),
Kulattha (
Dolichos biflorus
), Balam
(
Pavonia odorata
), Joratoota
(
Equisetum arvense
), and Shaka
(
Tectona grandis
) seed.
Clinical Pharmacology
Cystone tablet has antilithiatic and
lithotriptic, pH-renormalizing,
diuretic, antimicrobial, anti-adherent,
anti-inflammatory, demulcent,
spasmolytic, antioxidant, and tonic
actions.
The antilithiatic action of Cystone
prevents the deposition, accumulation,
and supersaturation of calculogenic
chemicals in urine. Cystone also
controls oxamide absorption from
the intestine. Cystone corrects the
crystalloid–colloid imbalance. Cystone
inhibits calculogenesis by reducing
stone-forming substances like oxalic
acid, calcium hydroxyproline, etc. The
lithotriptic action of Cystone helps
in the dissolution of calculi. Cystone
causes disintegration of the calculi and
crystals by acting on the mucin, which
binds the particles together. Cystone
offers diuretic action and flushes small
stones from the urinary tract.
The pH-renormalizing action of
Cystone provides cooling action
in the urinary system and relieves
burning micturition. Cystone provides
antimicrobial action against common
urinary pathogens responsible for
recurrent UTI.
Cystone is proven by a US FDA-
approved radiolabeled biotech assay to
prevent the adhesion of
Escherichia coli
to the uroepithelium. This action helps
in reducing the adhesion of
E coli
to
the cells lining the urinary tract and
promotes its expulsion along with the
natural flow of urine.
The anti-inflammatory action of
Cystone helps reduce inflammatory
changes in the mucosa of the urinary
tract, as seen commonly in UTI. The
demulcent action of Cystone soothes
and protects the irritated or inflamed
internal tissues of the urinary tract.
The antioxidant action of Cystone
prevents free radical damage to the
urinary tract. The antispasmodic
and anti-inflammatory actions of
Cystone provide relief from associated
symptoms of urolithiasis and UTI.
Indications
• For the prophylaxis and treatment
of adult and pediatric urolithiasis:
–
–
Calcium oxalate stones
–
–
Calcium phosphate stones
–
–
Uric acid and urate stones
• Crystalluria
• Prevention of post-lithotripsy
recurrence
• As an adjuvant in:
–
–
Acute and chronic UTI
–
–
Recurrent UTI
