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Drug info
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
–
–
Nonspecific urethritis
–
–
Nonspecific dysuria
–
–
Burning micturition
Dosage
Children:
½ to 1 teaspoonful twice
daily after meals.
Adults:
1 to 2 teaspoonfuls twice daily
after meals.
Recommend adequate water for
hydration. A higher dosage may be
recommended for more severe and
chronic conditions, and for older
children. To prevent recurrent UTI,
recommend Cystone along with
antibiotic therapy and continue for at
least 3 weeks.
Adverse Effects
No adverse effects have been reported.
Contraindications
No known contraindications.
Special Precautions
In complete ureter obstruction, it is
not advisable to recommend Cystone
syrup.
Drug Interactions
No clinically or biochemically
significant drug interactions have been
reported.
Presentation
Pilfer-proof bottles of 100 ml and
200 ml.
Pharmacological
Actions of Principal
Ingredients
1. Antilithiatic and
lithotriptic actions
T terrestris
,
D biflorus
, and
A racemosus
prevent the deposition,
accumulation, and supersaturation of
calculogenic chemicals in urine.
Aspartic and glutamic acids, a group
of amino acid compounds derived
from
B diffusa
, are the possible agents
for dissolving calcium oxalate calculi
in the kidneys.
Extracts of
T terrestris
and
S ligulata
show potential inhibitory effect on
the growth of urinary type calcium
hydrogen phosphate dihydrate
(CHPD) crystals, and thus act as
lithotriptics.
2. pH-renormalizing action
A racemosus
,
V zizanioides
, Narasara,
and Saindhava provide cooling
action in the urinary system and
relieve burning micturition by
renormalization of urinary pH.
3. Diuretic action
Cystone syrup flushes out small stones
and gravels due to the potent diuretic
actions of
T terrestris
,
C zedoaria
,
B diffusa
,
D biflorus
, and Yavakshara.
4. Antimicrobial action
Cystone syrup provides broad
antimicrobial action due to the
antimicrobial actions of
T terrestris
,
C zedoaria
, and
A racemosus
against
common urinary pathogens
responsible for recurrent UTI, which
leads to stone formation.
5. Anti-adherent action
Polyphenols present in Cystone syrup
are known to act as natural anti-
adhesion components responsible
for preventing the adhesion of
E coli
to the uroepithelium. This helps in
natural evacuation of
E coli
along with
the urine flow.
6. Anti-inflammatory action
C rotundus
and
B diffusa
have anti-
inflammatory actions that help to
reduce inflammatory changes in the
mucosa of the urinary tract, as seen
commonly in UTI.
7. Demulcent action
A racemosus
has demulcent property
due to its high content of mucilage
and soothes and protects the irritated
or inflamed internal tissues of the
urinary tract.
8. Spasmolytic action
Yavakshara,
B diffusa
, and Suvarchika
have antispasmodic action, and thus
provide great relief in dysuria.
9. Antioxidant action
B diffusa
and
A racemosus
are strong
antioxidant agents that prevent free
radical damage to the urinary tract.
10. Bioavailability-
enhancing property
Trikatu, an ayurvedic formulation
comprising a 1:1:1 ratio of dried fruits
of
P nigrum
,
P longum
, and dried
rhizomes of
Z officinale
, is widely
used to enhance the bioavailability
of drugs.
Piperine from
P nigrum
is absorbed
rapidly across the intestinal barrier
and acts as an apolar molecule
that forms an apolar complex with
drugs and solutes. This modulates
membrane dynamics due to its easy
partitioning, thus helps in efficient
permeability across the barriers, and
these membrane modulations help in
better bioavailability of nutrients and
medications.
