57
Drug info
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
–
–
Bone and joint infections
–
–
Urinary tract infections
• For early recovery in postoperative
conditions
• To reduce recurrence in infection-
prone individuals
• As an adjuvant to anti-infective
therapy
• Resistance to antibiotic therapy
Dosage
Drops:
0 to 3 months:
1 ml twice daily.
3 to 6 months:
1.5 ml twice daily.
6 months to 1 year:
3 ml twice daily.
1 to 2 years:
3.5 ml twice daily.
2 to 3 years:
4 ml twice daily.
3 to 4 years:
4.5 ml twice daily.
4 to 5 years:
5 ml twice daily.
Syrup:
Children:
1 to 2 teaspoonfuls three
times daily.
Adults:
2 teaspoonfuls three times
daily.
Tablet:
Children:
1 tablet twice daily.
Adults:
2 tablets twice daily till the
symptoms are relieved, followed by
1 tablet twice daily as maintenance
therapy.
Adverse Effects
No adverse effects have been reported.
Contraindications
Not recommended in early pregnancy.
Drug Interactions
No clinically significant drug
interactions have been reported.
Presentation
Drops:
Pilfer-proof bottles of 60 ml.
Syrup:
Pilfer-proof bottles of 200 ml.
Tablet:
Sealed packs of 60 tablets.
Pharmacological
Actions of Principal
Ingredients
1. Immunomodulatory
action
T cordifolia
has potent
immunomodulatory and
immunostimulatory actions, which
increase the levels of antibodies and
activate macrophages.
E officinalis
enhances cell survival,
increases phagocytosis and interferon-
gamma (IFN-
γ
) production.
Glycyrrhizin from
G glabra
potentiates the reticuloendothelial
system, enhances immunostimulation,
acts on macrophage function in vitro,
leading to stimulation of macrophages
de novo.
β
-glycyrrhetinic acid from
G glabra
is a potent inhibitor of the
classical complement pathway.
Glycyrrhizin from
G glabra
is known
to inhibit the production of IgE in
ovalbumin-induced asthma mice.
Roots of
I racemosa
possess potent
anti-allergic properties.
2. Antioxidant action
C wightii
,
R cordifolia
,
E officinalis
,
G glabra
, and
M pterygosperma
have
potent antioxidant actions.
3. Anti-inflammatory action
C wightii
has strong anti-inflammatory
potential.
G glabra
and
M pterygosperma
have
anti-inflammatory properties.
4. Antimicrobial action
T cordifolia
improves the phagocytic
and intracellular bactericidal capacities
of neutrophils.
Glycyrrhizin from
G glabra
exhibits
potent antiviral activity.
E officinalis
has antibacterial
properties, especially against
Escherichia coli
,
Klebsiella pneumoniae
,
Klebsiella ozaenae
,
Proteus mirabilis
,
Pseudomonas aeruginosa
,
Salmonella
typhi
,
Salmonella paratyphi
A and B,
and
Serratia marcescens
.
R cordifolia
has antibacterial
properties.
M pterygosperma
possesses
antibacterial and antiviral properties,
and inhibits the growth of gram-
positive and gram-negative bacteria
like
E coli
,
S typhi
,
S paratyphi
, etc.
The roots of
I racemosa
have
antimicrobial activity.
5. Other beneficial activities
T cordifolia
and
E officinalis
possess
antipyretic properties.
C wightii
is beneficial in respiratory
tract infections including chronic
tonsillitis, pharyngitis, chronic
bronchitis, nasal catarrh, and
laryngitis.
G glabra
is an expectorant, beneficial
in asthma, acute or chronic bronchitis,
and chronic cough.
