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Drug info
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
Cystone
®
(SYRUP)
The natural choice in urinary calculi & UTI
Introduction
Cystone syrup, a phytopharmaceutical
formulation, is recommended for
the comprehensive management
of urolithiasis and urinary tract
infections (UTIs). Cystone syrup
expels kidney stones and ureteric
stones and prevents their recurrence.
Cystone syrup is safe and effective
in the management of pediatric
urolithiasis and UTI and causes
significant reduction of associated
symptoms.
Composition
Each 5 ml of Cystone syrup contains:
Exts.
Gokshura (
Tribulus terrestris
) 91 mg
Punarnava (
Boerhaavia diffusa
) 67 mg
Pashanabheda
(
Saxifraga ligulata
)
53 mg
Mustaka (
Cyperus rotundus
)
42 mg
Shatavari
(
Asparagus racemosus
)
21 mg
Kulattha (
Dolichos biflorus
)
21 mg
Ushira (
Vetiveria zizanioides
) 21 mg
Trikatu
20 mg
Karchura (
Curcuma zedoaria
) 14 mg
Pdrs.
Saindhava
50 mg
Suvarchika
42.5 mg
Yavakshara
5 mg
Narasara
2.5 mg
Clinical Pharmacology
Cystone syrup has antilithiatic and
lithotriptic, pH-renormalizing,
diuretic, antimicrobial, anti-adherent,
anti-inflammatory, demulcent,
spasmolytic, and antioxidant actions
along with bioavailability-enhancing
property.
The antilithiatic action of Cystone
prevents the deposition, accumulation,
and supersaturation of calculogenic
chemicals in urine. Cystone also
controls oxamide absorption from
the intestine. Cystone corrects the
crystalloid–colloid imbalance. Cystone
inhibits calculogenesis by reducing
stone-forming substances like oxalic
acid, calcium hydroxyproline, etc. The
lithotriptic action of Cystone helps
in the dissolution of calculi. Cystone
causes disintegration of the calculi and
crystals by acting on the mucin, which
binds the particles together. Cystone
offers diuretic action and flushes out
small stones from the urinary tract.
The pH-renormalizing action of
Cystone provides cooling action
in the urinary system and relieves
burning micturition. Cystone provides
antimicrobial action against common
urinary pathogens responsible for
recurrent UTI.
Cystone is proven by a US FDA-
approved radiolabeled biotech assay to
prevent the adhesion of
Escherichia coli
to the uroepithelium. This action helps
in reducing the adhesion of
E coli
to
the cells lining the urinary tract and
promotes its expulsion along with the
natural flow of urine.
The anti-inflammatory action
of Cystone helps in reducing
inflammatory changes in the mucosa
of the urinary tract, as seen commonly
in UTI. The demulcent action of
Cystone soothes and protects the
irritated or inflamed internal tissues
of the urinary tract. The antioxidant
action of Cystone prevents free radical
damage to the urinary tract. The
antispasmodic and anti-inflammatory
actions of Cystone provide relief from
associated symptoms of urolithiasis
and UTI.
Indications
• For the prophylaxis and treatment
of adult and pediatric urolithiasis
such as:
–
–
Calcium oxalate stones
–
–
Calcium phosphate stones
–
–
Uric acid and urate stones
• Crystalluria
• Prevention of post-lithotripsy
recurrence
• As an adjuvant in:
–
–
Acute and chronic UTI
–
–
Recurrent UTI
