43
Abstracts
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
Orthopedics
Bone Density and Bone Metabolism in Patients
With Inflammatory Bowel Disease
Shirazi KM, et al
Saudi J Gastroenterol
. 2012;18(4):241–247.
This study was aimed to evaluate bone mineral density
(BMD) in patients with inflammatory bowel disease (IBD)
and its relationship with bone metabolism in a group of
Iranian patients.
A cross-sectional study was conducted on patients with IBD
to assess BMD status and serum biochemical factors. Two
hundred patients with IBD were enrolled in the study. One
hundred and eighty three (91.5%) patients were identified
as having ulcerative colitis (UC) and 17 (8.5%) as having
Crohn disease (CD). These results for those with CD were
76.5% and 70.6%, respectively. The mean of femoral neck
and lumbar T-scores in patients with UC were - 1.14 and
- 1.38, and in patients with CD were - 1.24 and - 1.47,
respectively (
P
> .05). The mean (± SD) levels of ALP and
25-OH vitamin D in both the groups were in the normal
range, and in comparison between groups (UC and CD),
no significant differences were observed (
P
= .20 for ALP
and
P
= .44 for 25-OH vitamin D).
The high prevalence of low BMD in the Iranian population
with IBD needs attention. The subclinical vitamin D
deficiency may contribute to bone loss in IBD patients,
which is more pronounced in patients with UC in this
study because of the small population of patients with CD.
Chronic Kidney Disease and the Risk of Incident
Gout Among Middle-aged Men: A Seven-year
Prospective Observational Study
Krishnan E
Arthritis Rheum
. 2013;65(12):3271–3278.
The kidney is the major organ that facilitates excretion of
urate in humans. Surprisingly, few studies have assessed
whether reduced glomerular filtration rate (GFR) and/
or kidney damage is associated with a higher incidence
of gout, and this study was undertaken to address this
question.
Data from a 7-year follow up of patients enrolled in
the Multiple Risk Factor Intervention Trial, a primary
prevention trial for cardiovascular disease among 12,866
men aged 35 to 57 years, were used for the present
investigation.
Overall, there were 722 cases of physician-diagnosed
incident gout over 76,602 person-years of follow up. The
standardized incidence ratio of gout among those with
chronic kidney disease was 1,217. Each standard deviation
decline in the estimated GFR was associated with an HR of
1.43. Including the serum urate level, as well as the urate-
chronic kidney disease interaction term, as variables in the
second analysis did not attenuate the HR. Proteinuria and
hematuria, 2 markers of kidney damage, were associated
with an elevated risk of gout independent of the estimated
GFR.
Chronic kidney disease manifesting as reduced glomerular
function or as presence of blood or protein in the urine
increases the risk of incident gout.
