36
Abstracts
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
Dermatology
Childhood Atopic Dermatitis and Warts are
Associated With Increased Risk of Infection: A
US Population-based Study
Silverberg JI, Silverberg NB
J Allergy Clin Immunol
. October 3, 2013 (doi: 10.1016/j.
jaci.2013.08.012).
The goal of this study was to determine whether childhood
atopic dermatitis (AD) is associated with increased risk of
warts, extracutaneous infections, and other atopic diseases
and how these disorders co-segregate.
The 2007 National Health Interview Survey from a
nationally representative sample of 9417 children age 0 to
17 years was used.
Children with AD and other atopic disease had higher odds
of warts. In contrast, children with AD with or without
other atopic diseases had higher odds of extracutaneous
infections, including strep throat, sore throat, head or chest
cold, influenza/pneumonia, sinus infections, recurrent ear
infections, chickenpox, and urinary tract infections (
P
<
.0001). Children with AD and other atopic diseases had a
higher number of infections than those with either disorder
by itself (
P
< .0001). Warts were also associated with
increased odds of all extracutaneous infections (
P
< .0001).
Children with warts and AD had a higher number of
infections than those with either disorder alone (
P
< .0001).
The associations between childhood AD, atopic disease,
warts, and extracutaneous infections suggest that barrier
disruption, immune disruption, or both contribute to
susceptibility to warts and extracutaneous infections in
children.
A Retrospective Analysis of Dermatological
Lesions in Kidney Transplant Patients
Castello M, et al
Indian J Med Res
. 2013;137(6):1188–1192.
This study was undertaken to evaluate the cutaneous
and mucosal diseases after kidney transplantation, and
to investigate the association between these and different
immunosuppressive protocols and/or demographic features.
A retrospective analysis was done using medical records
of kidney transplantation at the Transplant Unit of
Fondazione Pavia, Italy. The study included 183 patients
with transplant. Induction therapy was basiliximab and
steroids based; maintenance therapy included combination-
regimes from cyclosporine, tacrolimus, steroids,
mycophenolate mofetil (MM), mycophenolic acid (MPA),
rapamycin, everolimus. Anti-rejection therapy was steroid
and/or thymoglobulines based. Diagnosis of cutaneous
disease was made through examination of skin, mucous
membranes, nails, and hair.
Skin and mucosal diseases were reported in 173 (95.7%)
of patients; 88 (50.81%) showed viral lesions; 92 (53.01%)
immunosuppression-related lesions; 28 (16.39%) benign
tumors; 26 (15.3%) precancers/neoplastic lesions; 24
(14.21%) mycosis; 16 (9.29%) cutaneous xerosis, 15 (8.74%)
dermatitis, while absence of cutaneous disease was evident
only in 8 (4.37%) cases. An association between drug
side effects and anti-rejection treatment (
P
≤ .01) and/
or calcineurin-inhibitors (CNI) exposure (
P
≤ .01) was
found. Longer exposure to immunosuppressive drugs
(> 60 months) was associated with pre-malignancy and
malignancy lesions.
Cutaneous diseases are frequent in kidney transplanted
patients. Continuous skin monitoring is necessary to make
an early diagnosis and to start appropriate treatment.
