39
Abstracts
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
Hepatology
The Ratio of Aspartate Aminotransferase to
Alanine Aminotransferase: The Correlation of
Value With Underlying Severity of Alcoholic
Liver Disease
Gurung RB, et al
Kathmandu Univ Med J
. 2013;11(43):233–236.
Authors elucidated the study values of aspartate
aminotransferase to alanine aminotransferase (AST/ALT)
ratio in correlation with clinical severity of illness due to
alcoholic liver disease.
This is a retrospective study. Inpatient records of all the
patients admitted with diagnosis of alcoholic liver disease
from July 2009 to June 2011 were analyzed. The AST/ALT
ratio and child’s grading of all the patients were calculated
from the documented biochemical and clinical parameters
on admission. Demographic profile of all the patients were
also recorded and analyzed.
A total of 138 patients diagnosed as having alcoholic liver
disease since July 2009 to June 2011 were analyzed. Among
138 patients, Mongolians were found to have the highest
prevalence of alcoholic liver disease (38.8%), followed by
Newars (33.6%), Brahmin and Chhetri (19.1%), and Dalit
(7.2%). With respect to AST/ALT ratio and child’s grading
of ALD, the mean AST/ALT ratio was found to be 3.03 ±
2.24 in those patients who had child’s grade C; likewise the
mean AST/ALT ratio was 2.28 ± 1.14, and 1.68 ± 0.83 in
patients with child B and child A respectively.
The higher value of AST/ALT ratio is indicative of more
severe liver damage due to alcohol.
Association of Nonalcoholic Fatty Liver Disease
With Urolithiasis
Einollahi B, et al
Endocr Regul
. 2013;47(1):27–32.
In this study, a possible relationship between fatty liver
with renal calculi and urolithiasis is investigated. In a
cross sectional study, a total of 11,245 ultrasonography
reports revealing the condition of fatty liver, urolithiasis,
or a combination of both of them, were categorized and
evaluated statistically.
We found 8% frequency of urolithiasis among subjects
with healthy liver. Nonalcoholic fatty liver disease
(NAFLD) was identified in 30%, while urolithiasis in 11%
subjects from all individuals studied. The present study
diagnosed urolithiasis in 17% of patients with fatty liver.
Its occurrence was more common in men than women.
Data revealed more common diagnosis of fatty liver (48%)
in patients with urolithiasis, which was also higher in
males than females. The higher NAFLD was linked with
urolithiasis, indicating a greater chance of their association.
Interestingly, the detection frequency of urolithiasis in
the patients with NAFLD was also markedly higher. The
NAFLD appears to be an independent variable as a risk
factor for stone formation.
The present study indicates that the prevalence of
urolithiasis is significantly higher in patients with NAFLD
than healthy subjects. It is suggested that lipid peroxidation,
oxidative stress and changes in the urinary constituents in
those with NAFLD may be considered as a risk factor in the
progression of stone formations.
