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Clinical Practice Pearls
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
Clin al Insight
Safety and Efficacy of Diarex Syrup in Children
Suffering From Diarrhoea
Muralikumar V
Data on file.
A B S T R A C T
This study was conducted to evaluate the
safety and efficacy of Diarex syrup in children
suffering from diarrhea.
Twenty children presenting with abnormal stool consist-
ency, nausea, and vomiting were enrolled for the study. All
of them underwent physical examination at entry. All children
were advised to take Diarex syrup at the prescribed dosage for
7 days. Symptom evaluation was done on day 3 and day 7 of the
treatment.
Diarex syrup showed significant improvements in symptoms from
day 3 onward in most children and further improvement in symptoms
was seen on day 7 with a significance of
P
< .001. There were no adverse
events observed or reported during the study. Thus, Diarex is safe and
effective in the treatment of diarrhea.
Key Words:
Diarrhea, nausea, vomiting, Diarex syrup
Introduction
Infections of the gastrointestinal
tract produce a variety of symptoms
and can be due to a large number of
different infective agents. The most
common symptom is diarrhea, which
leads to considerable morbidity and
mortality, worldwide. Recurrent bouts
of gastroenteritis lead to nutritional
deficiencies, while malnutrition
may increase susceptibility to
further infections. The types and
severity of gastrointestinal infections
are determined by a variety of
epidemiological factors. Different
age groups will have different risks
with the extremes of age being the
most vulnerable. Underlying medical
conditions, such as, autoimmune
diseases and patients receiving
immunosuppressive drugs including
corticosteroids, may influence the
response to infections.
Overcrowding and poor sanitation
predispose to gastrointestinal
infection. The main stay of managing
diarrheal diseases is the recognition
and correction of water and electrolyte
depletion, antidiarrheal agents, and
antimicrobial therapy.
