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Clinical insight
P R O B E
• V o l . L I I I • N o . 3 • A p r – J u n 2 0 1 4
Safety and Efficacy of Lukol Syrup: A Randomized,
Double Blind Placebo Controlled Clinical Study
Moharana PK
Data on file.
A B S T R A C T
This study was conducted to evaluate the
clinical safety and efficacy of Lukol syrup in
relieving the symptoms associated with leukorrhea.
Seventy women presenting with symptoms of leukorrhea
were enrolled for the study and randomized into 2 groups,
namely, Lukol group and the placebo group. Women in the
Lukol group were advised to take Lukol syrup at the prescribed
dosage. Effect of Lukol on various parameters was studied on week
2 and week 4 of the therapy. The obtained results were subject to
statistical analysis.
At the end of the study, women in the Lukol group showed significant
relief from the symptoms of leukorrhea. No adverse events were reported
during the study period. Thus, Lukol is safe and effective in the treatment
of leukorrhea.
Key Words:
Leukorrhea, Lukol syrup, vaginal discharge,
Trichomonas
vaginalis
,
Candida albicans
Introduction
Leukorrhea is one of the most
common complaints encountered
in gynecological practice. The term
“leukorrhea” is applied to cases
of abnormal vaginal discharge,
nonhemorrhagic in nature, which
is not caused by neoplasm or
other serious organic diseases. It
is considered that changes in the
vaginal epithelium, changes in the
normal bacterial flora, and pH of
the vaginal secretion predispose to
leukorrhea. Chronic illness, fatigue,
malnutrition, emotional disturbances,
chronic retroverted uterus, congestive
cardiac failure, gonococcal and
monilial infections, vulvovaginitis,
lesions of the vaginal wall and uterine
cervix have all been associated
with leukorrhea. An increase in
normal vaginal secretion occurs
physiologically at puberty, during
pregnancy, and in some women
during the premenstrual phase.
Nonpathological leukorrhea can be
cervical or vaginal. In cervical
leukorrhea, cervical discharge is
mucoid in nature and can arise due
to chronic cervicitis, cervical erosion,
mucous polyp, etc. Vaginal leukorrhea
