T h e r a p e u t i c I n d e x 90 Contraindications No known contraindications. Presentation Transparent lamitube of 30 g. Pharmacological Actions of Principal Ingredients 1. Nitric oxide synthesis-enhancing action: Himcolin causes vascular engorgement of the penis, and thus strengthens and sustains erection. Withania somnifera has NO synthesis-enhancing activity, which relaxes the corporal smooth muscle, and promotes endothelium-derived penile vasodilation and erection. Vitex negundo has analgesic and anti-inflammatory activities. It causes vasodilation and has a soothing effect on the area applied. 2. Smooth muscle-relaxant action: Himcolin causes vascular engorgement of the penis and strengthens and sustains erection due to its additional smooth muscle-relaxant action. Cinnamomum cassia acts as a vascular and nervine stimulant, thereby accelerating smooth muscle relaxation. Celastrus paniculatus relaxes penile vascular smooth muscles, which causes vasodilation and results in penile erection. It acts as a rubefacient, which stimulates the sensitive nerves of the penis. Prunus amygdalus has demulcent and nervine tonic properties, which enhance the smooth muscle-relaxant action. 3. Antioxidant action: Celastrus paniculatus and Prunus amygdalus have potent antioxidant activity. Vitex negundo, Myristica fragrans, Syzygium aromaticum, Cinnamomum cassia, Withania somnifera, and Asparagus racemosus have potent antioxidant action that controls and prevents local oxidative damage, and corrects the impaired cavernosal function in ED. 4. Aphrodisiac action: Myristica fragrans, Syzygium aromaticum, and Hibiscus abelmoschus have aphrodisiac activity. Himcolin® (gel)
RkJQdWJsaXNoZXIy MjMwNjM2Nw==