T h e r a p e u t i c I n d e x 79 Withanolides from Withania somnifera promote the growth of axons and dendrites. Asparagus racemosus, Tinospora cordifolia, Glycyrrhiza glabra, and Vitis vinifera are potent adaptogens. Shilajeet exhibits antistress activity. Centella asiatica is a nervine tonic that helps improve memory and combats mental fatigue. 4. Nootropic action: A nootropic drug increases learning capacity and arrests the effects of aging. Vitis vinifera, Shilajeet, Centella asiatica, Withania somnifera, and Glycyrrhiza glabra have potent nootropic activity. Celastrus paniculatus possesses central nervous system (CNS)-stimulant activity. It improves alertness, enhances intellect, and sharpens memory. Myristica fragrans has memory-enhancing activity. Crocin in Crocus sativus improves learning behavior, and is useful in neurodegenerative disorders. Curcuma longa has antidepressant activity. 5. Immunomodulatory action: Immunomodulation enables the body to recognize and fight microorganisms and foreign substances that are potentially harmful. Withania somnifera, Asparagus racemosus, Centella asiatica, Argyreia speciosa, Cichorium intybus, Berberis aristata, Allium sativum, Boerhaavia diffusa, Tinospora cordifolia, and Phoenix dactylifera have potent immunomodulatory action. Glycyrrhiza glabra possesses remarkable immunomodulatory property. 6. Cardioprotective action: Geriforte ingredients have pleomorphic cardioprotective effects, which include lipid modulation, prevention of lesion initiation, reduction in lesion progression and myocardial damage, repair of injuries, enhancement in myocardial perfusion, protection against immune injury, modulation of vascular tone, anti-inflammatory property, profibrinolytic and anticoagulant activities, mobilization of endothelial progenitor cells for repair, angiogenic effect, and, antiatherosclerotic and endothelial dysfunction-renormalizing activities. Terminalia arjuna, Withania somnifera, Terminalia chebula, Curcuma longa, Berberis aristata, Allium cepa, Allium sativum, Emblica officinalis, Chyavanaprasha, Myristica fragrans, Crocus sativus, Vitis vinifera, and Embelia ribes have cardioprotective effect. Myristica fragrans has hypolipidemic activity. The extract of Cichorium intybus protects LDL against oxidative attack. Vitis vinifera prevents oxidation of LDL. Embelia ribes decreases blood glucose, serum total cholesterol, triglycerides, and increases HDL cholesterol levels. Centella asiatica prevents deterioration of microcirculation due to diabetic microangiopathy. Geriforte® (syrup, tablet)
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