T h e r a p e u t i c I n d e x 78 Dosage Syrup: Initially, 2 teaspoonsful (10 mL) twice daily, followed by 1 teaspoonful (5 mL) twice daily. Tablet: Initially, 2 tablets twice daily, followed by 1 tablet twice daily. Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Presentation Syrup: Pilfer-proof bottle of 200 mL. Tablet: Sealed pack of 100 tablets. Pharmacological Actions of Principal Ingredients 1. Antioxidant action: Antioxidants are involved in the prevention of cellular damage. Capparis spinosa, Terminalia arjuna, Withania somnifera, Asparagus racemosus, Glycyrrhiza glabra, Terminalia chebula, Mucuna pruriens, Syzygium aromaticum, Curcuma longa, Cichorium intybus, Solanum nigrum, Emblica officinalis, Allium cepa, Allium sativum, Boerhaavia diffusa, Tinospora cordifolia, Raphanus sativus, Tribulus terrestris, Apium graveolens, Foeniculum vulgare, Coriandrum sativum, Vitis vinifera, and Phoenix dactylifera have potent antioxidant action, which corrects and prevents the free radical-induced oxidative damage to various organs and systems. Emblica officinalis is the richest natural source of vitamin C, and a natural rejuvenator and antioxidant. It has potent cardioprotective activity and reduces oxidative stress on the myocardium. Centella asiatica reduces oxidative stress in the brain. Celastrus paniculatus has neuroprotective activity and prevents oxidative damage to neurons. 2. Neuroprotective action: Chronic neurodegenerations (Alzheimer’s and Parkinson’s disease) share a common mechanism of neuronal death, with acute forms of neurodegeneration. The relationship between neurodegeneration, excitotoxicity, cellular calcium overload, metabolic failure, and oxidative stress has been well established, which emphasizes the role of mitochondrial dysfunction in both necrotic and apoptotic cell death. Various neuroprotective compounds have been researched for developing clinically useful neuroprotective interventions. The various ingredients of Geriforte have been proven for neuroprotective activity. Centella asiatica prevents cognitive impairment from oxidative stress. Withania somnifera prevents neural damage to the cortex, hippocampus and spinal cord, and reduces the number of degenerating cells in the brain. Asparagus racemosus has neuroprotective activity. Celastrus paniculatus, Crocus sativus, and Tinospora cordifolia have strong neuroprotective action. Mucuna pruriens is a natural source of L-dopa, which has antiparkinsonian activity. 3. Adaptogenic action: Adaptogens help the body adapt to physiological and psychological stress and increase stamina and overall performance. Geriforte® (syrup, tablet)
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