T h e r a p e u t i c I n d e x 74 Adverse Effects No adverse effects have been reported. Contraindications • Not recommended in the first trimester of pregnancy and in women with poor obstetric history • Use under medical supervision in the second and third trimesters, if required Presentation Sealed pack of 100 tablets. Pharmacological Actions of Principal Ingredients 1. Renormalization of intestinal transit time: (6)-Shogaol from Zingiber officinale renormalizes the intestinal transit time, which helps in the reduction of abdominal bloating and discomfort. Triphala helps in digestion and intestinal motility, and also relieves gaseous distension. 2. Prebiotic action: Plumbago zeylanica has strong prebiotic action that renormalizes the disturbed intestinal microflora, essential for numerous metabolic processes of digestion. 3. Antiflatulent action: Piper nigrum has antiflatulent activity, and is used in various gastrointestinal (GI) ailments. Zingiber officinale relieves flatulence, and thus, is useful in colic, abdominal pain, and spasms. Varatika bhasma is well known for its antiflatulent property, useful in gastritis, duodenitis, and other GI disorders. Shankha bhasma has digestive and appetizer properties, helpful in providing antiflatulent action, which in turn is useful in providing relief in gastritis, duodenitis, and other common digestive disorders. 4. Anti-inflammatory action: Piper nigrum, Zingiber officinale, and Moringa pterygosperma have potent anti-inflammatory activity. 5. Cholagogue and membrane-modulating actions: Piper nigrum and Zingiber officinale promote biliary discharge and improve fatty food metabolism. Piperine from Piper nigrum is absorbed rapidly across the intestinal barrier, and acts as an apolar molecule that forms an apolar complex with drugs and solutes. This modulates the membrane dynamics, thus helping in efficient permeability across the barriers. These membrane modulations help in better bioavailability of nutrients and medications. 6. Antioxidant action: Functional GI diseases such as non-ulcer dyspepsia (NUD) are correlated to inflammatory processes, where reactive oxygen species (ROS) play a crucial role. Piper nigrum, Zingiber officinale, Mentha arvensis, Moringa pterygosperma, Citrus limon, Plumbago zeylanica, Gasex® (tablet)
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