T h e r a p e u t i c I n d e x 64 Pharmacological Actions of Principal Ingredients 1. Phytoestrogenic action: Asparagus racemosus and Saraca indica have potent estrogenic action due to phytoestrogens. Phytoestrogens repair the endometrium, regulate estrogen levels, and help heal the inflamed endometrium during menstruation. 2. Gonadotropin-agonist action: The gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), released from the anterior pituitary, regulate follicle maturation, ovulation, and estrogen and progesterone levels. Symplocos racemosa and Asparagus racemosus have potent gonadotropin-agonist action that improves fertility by regulating ovarian hormones. Aloe vera improves fertility by regulating hormone levels. 3. Antihemorrhagic action: Saraca indica and Adhatoda vasica have antihemorrhagic activity, and thus are useful remedies in DUB. They are especially used as uterine hemostatics in menorrhagia and metrorrhagia. 4. Antimicrobial action: Chronic or recurrent pelvic infection of the upper and lower genital tract is the primary reason for infertility, and is also implicated in dysmenorrhea. Aloe vera and Solanum nigrum have broad-spectrum antimicrobial activity against microorganisms responsible for chronic or recurrent pelvic infection of the upper and lower genital tract. Hemidesmus indicus has potent antibacterial activity and a healing effect on the uterus, thus helping in uterine involution. Yashada bhasma has antiseptic, astringent, and wound-healing properties. 5. Anti-inflammatory and analgesic actions: Chronic pelvic inflammatory disease (PID) leads to endometrial proliferation and hyperplasia, which subsequently manifests as dysmenorrhea, menorrhagia, and infertility. Aloe vera, Cyperus rotundus, and Adhatoda vasica have strong anti-inflammatory and analgesic activities, which relieve the pain of dysmenorrhea. Bombax malabaricum and Symplocos racemosa have analgesic action. 6. Antispasmodic action: Asparagus racemosus and Acacia arabica have antispasmodic effect. 7. Antioxidant action: Oxidative stress has been implicated in the etiopathogenesis of dysmenorrhea, due to increase in prostaglandins and other chemomediator production. This leads to platelet aggregation, vasoconstriction, and dysrhythmic contractions. Tinospora cordifolia, Asparagus racemosus, Santalum album, Triphala, Boerhaavia diffusa, Solanum nigrum, and Cocus nucifera are antioxidants that prevent oxidative stress. Evecare® (capsule, syrup)
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