T h e r a p e u t i c I n d e x 56 10. Antihypercholesterolemic action: Diabecon effectively reduces the risk factors for coronary artery disease (CAD) by modulating the lipid profile through its antihypercholesterolemic property. Diabecon reduces the levels of free fatty acids and renormalizes lipid abnormalities associated with NIDDM. Commiphora wightii, Gymnema sylvestre, Glycyrrhiza glabra, Casearia esculenta, Syzygium cuminii, Tinospora cordifolia, Tribulus terrestris, Phyllanthus amarus, Aloe vera, Piper nigrum, Ocimum sanctum, Curcuma longa, Pterocarpus marsupium, Boerhaavia diffusa, and Trikatu have potent antihypercholesterolemic activity. Momordica charantia decreases elevated serum levels of cholesterol, free fatty acids, and triglycerides. 11. Adaptogenic action: Stress is a key factor, which influences the progression of diabetes mellitus and its complications. Tinospora cordifolia, Asparagus racemosus, and Ocimum sanctum have potent adaptogenic action that helps control disease-associated stress. 12. Antioxidant action: Diabecon increases localized superoxide dismutase activity, which prevents oxidative damage (by formation of free radicals) to b-cells in islets of Langerhans, and thereby protects b-cells from destruction. Diabetic endothelial dysfunction is associated with diabetic vasculopathy, and control of oxidative damage is crucial. Swertia chirata, Tinospora cordifolia, Aloe vera, Triphala, Piper nigrum, and Ocimum sanctum have potent antioxidant activity, which offers protection from oxidative damage in diabetic vasculopathy. 13. Other beneficial activities: Shilajeet relieves thirst, polyuria and exhaustion, acts as a biocatalyst, and is useful in diabetic albuminuria. Tinospora cordifolia, an immunomodulator, enhances immunity and a general sense of well-being. Diabecon® (tablet, DS tablet)
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