T h e r a p e u t i c I n d e x 54 • Type 2 diabetes with micro- and macrovascular complications: – NIDDM with early retinopathy – NIDDM with microalbuminuria – NIDDM with hyperlipidemia Dosage Tablet Monotherapy: 2 tablets twice daily before food in newly detected type 2 diabetes. Adjuvant therapy: 1 tablet twice daily before food as an adjuvant to OHAs or insulin. DS tablet Monotherapy: 1 tablet twice daily before food. Adjuvant therapy: 1 tablet once daily before food. The dosage may be titrated depending on the patient’s response. Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Special Precautions Diabecon is safe. However, when used as an adjuvant in NIDDM and IDDM, it is advisable to titrate the dose of OHAs and insulin under careful medical supervision. Presentation Tablet: Sealed pack of 60 tablets. DS tablet: Sealed pack of 60 tablets. Pharmacological Actions of Principal Ingredients 1. Insulin secretagogue and insulinomimetic actions: Diabecon increases insulin secretion through the insulin secretagogue and insulinomimetic actions of Momordica charantia, Pterocarpus marsupium, Tinospora cordifolia, Tribulus terrestris, Aloe vera, Ocimum sanctum, Piper nigrum, Curcuma longa, and Abutilon indicum. Gymnema sylvestre stimulates endogenous insulin secretion by altering the cell membrane permeability, while Boerhaavia diffusa enhances plasma insulin levels. 2. Antihyperglycemic action: Effective hyperglycemic control is crucially important to prevent the micro- and macrovascular complications of diabetes mellitus. Gymnema sylvestre, Shilajeet, Casearia esculenta, Syzygium cuminii, Tinospora cordifolia, Phyllanthus amarus, Triphala, Momordica charantia, and Ocimum sanctum decrease hepatic glucose production and prevent hyperglycemia. Pterocarpus marsupium has hypoglycemic action and reduces glucose absorption from the GI tract. Diabecon® (tablet, DS tablet)
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