T h e r a p e u t i c I n d e x 44 Pharmacological Actions of Principal Ingredients 1. Antilithiatic and lithotriptic actions: Cystone tablet exhibits antilithiatic action that helps to prevent the deposition, accumulation, and supersaturation of calculogenic chemicals in urine, and thus inhibits calculogenesis. Cystone tablet corrects the crystalloid–colloid imbalance. Cystone tablet possesses lithotriptic action that dissolves the mucin, which binds stone particles. Didymocarpus pedicellata, Dolichos biflorus, Saxifraga ligulata, Tribulus terrestris, and Equisetum arvense prevent the deposition, accumulation, and supersaturation of calculogenic chemicals in urine, while Hajrul yahood bhasma has lithotriptic property. Rubia cordifolia has ruberythric acid, which dissolves oxalate stones present in the urinary tract, thereby facilitating their expulsion without recourse to surgery. 2. pH-renormalizing action: Cystone tablet renormalizes the urinary pH and relieves burning micturition. Equisetum arvense renormalizes and maintains the urinary pH within the alkaline range—from 7.5 to 8.0. 3. Diuretic action: Cystone tablet offers diuretic action and flushes small stones and gravel. Didymocarpus pedicellata, Saxifraga ligulata, Achyranthes aspera, Onosma bracteatum, Tectona grandis, and Hajrul yahood bhasma have potent diuretic actions. Cyperus scariosus exhibits diuretic activity, and is also useful in maintaining genitourinary health. 4. Antimicrobial action: Cystone tablet has broad antimicrobial action against common urinary pathogens. Saxifraga ligulata, Rubia cordifolia, Ocimum basilicum, Tribulus terrestris, and Equisetum arvense have broad-spectrum antimicrobial action against common urinary pathogens responsible for recurrent UTI. 5. Anti-adherent action: The polyphenols present in Cystone tablet are known to act as natural anti-adhesion components responsible for preventing the adhesion of Escherichia coli to the uroepithelium. This helps in natural evacuation of Escherichia coli along with the urine flow. 6. Anti-inflammatory action: Cyperus scariosus, Rubia cordifolia, Vernonia cinerea, Shilajeet, Ocimum basilicum, Equisetum arvense, and Saxifraga ligulata possess anti-inflammatory activity. 7. Spasmolytic action: Cystone tablet exhibits spasmolytic action and relieves renal colic. Onosma bracteatum is a powerful antispasmodic agent. Cystone® (tablet)
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