T h e r a p e u t i c I n d e x 38 Contraindications No known contraindications. Drug Interactions No clinically significant drug interactions have been reported. Presentation Sealed pack of 60 tablets. Pharmacological Actions of Principal Ingredients 1. Androgenic action: Inadequate circulating testosterone levels result in male sexual dysfunction. Protodioscin, a phytochemical agent in Tribulus terrestris and a precursor of testosterone, converts to dehydroepiandrosterone (DHEA) and improves flow-mediated vasodilation of the penile arteries along with spermatogenesis. The vasodilation is dependent on the endothelium-derived nitric oxide (NO), as NO is the principal mediator of vascular smooth muscle relaxation in erectile tissue and penile arteries. Mucuna pruriens increases sperm count and testosterone levels, and thus, has a beneficial action in male sexual disorders. Leptadenia reticulata treats sexual disorders like improper erection, night emission, premature ejaculation, spermatorrhea, and functional impotence. 2. Aphrodisiac action: Withania somnifera, Svarnavanga, Argyreia speciosa, Lactuca serriola, Parmelia perlata, Mucuna pruriens, and Tribulus terrestris are aphrodisiacs that improve sexual desire and drive, which subsequently improves sexual performance. 3. Fertility-enhancing action: Asteracantha longifolia, Svarnavanga, Argyreia speciosa, and Tribulus terrestris are helpful in impotence, spermatorrhea, and seminal debilities. 4. Anxiolytic action: Rauwolfia serpentina has remarkable anxiolytic action, which controls anxiety associated with sexual performance. Its anxiolytic action is due to raubasine, which has benzodiazepine-agonist type activity. Lactuca serriola has anxiolytic property, which is supported by its sedative activity. 5. Antioxidant action: Asteracantha longifolia, Lactuca serriola, and Mucuna pruriens are antioxidants. Confido® (tablet)
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