T h e r a p e u t i c I n d e x 36 Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Precautions • To be used exclusively for external application on acne lesions. • It is advisable to confirm safety of topical application in individuals with a history of allergy. If any allergic or hypersensitivity reaction occurs, Clarina anti-acne cream should be discontinued. • Severe reaction may require conventional treatment. Presentation Lamitube of 30 g. Pharmacological Actions of Principal Ingredients 1. Antibacterial action: Alternanthera sessilis and Aloe barbadensis have potent antibacterial activity. Rubia cordifolia has potent antibacterial activity that helps control infection in acne lesions. Tankana is an effective antibacterial agent, useful in treating superficial dermal infections. Yashada bhasma possesses antiseptic property. 2. Anti-inflammatory action: Clarina anti-acne cream has significant anti-inflammatory action that helps reduce the inflammation associated with acne. Aloe barbadensis and Rubia cordifolia inhibit Propionibacterium acnes-induced inflammatory mediators. Aloe barbadensis has potent anti-inflammatory activity. It inhibits the production of inflammatory mediators— prostaglandin E2, interleukin-8—and has a dose-dependent inhibitory effect on reactive oxygen metabolite production. 3. Wound-healing action: Aloe barbadensis has wound-healing property. Yashada bhasma accelerates wound-healing and has beneficial effects in treating acne. 4. Astringent action: Rubia cordifolia, Tankana, and Yashada bhasma possess significant astringent action that causes shrinkage of mucous membranes or exposed tissues, and checks discharge of blood serum or pus-like fluid from acne mass. 5. Emollient and soothing effects: Aloe barbadensis has a natural sunscreen effect that moisturizes the skin. Prunus amygdalus and Alternanthera sessilis have cooling, soothing, and emollient effects that relieve burning sensation and pruritus. Yashada bhasma helps in keeping the skin soft and supple. Clarina® (anti-acne cream)
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