T h e r a p e u t i c I n d e x 242 Special Precautions If testicular functions do not improve in spite of long-term treatment with Speman, as a monotherapy or as an adjuvant to other spermatogenic drugs, additional investigations may be required. Presentation Sealed pack of 60 tablets. Pharmacological Actions of Principal Ingredients 1. Androgenic action: Speman, due to its specific composition, promotes spermatogenesis by improving testosterone levels in men with testicular spermatogenic failure, which is enabled by specialized herbs. Protodioscin from Tribulus terrestris converts to dehydroepiandrosterone (DHEA), a precursor of testosterone, which improves sexual desire and sustains penile erection. Mucuna pruriens has aphrodisiac activity. Leptadenia reticulata is used as a restorative and stimulant, and is useful as an adjuvant to aphrodisiac medications. Parmelia perlata, an aphrodisiac, is helpful in seminal weakness. Asteracantha longifolia is helpful in impotence, spermatorrhea, and seminal debilities. Svarnavanga is an invigorator, aphrodisiac, and rejuvenator, and it induces health and vigor and improves semen quality. Argyreia speciosa, an aphrodisiac, is used in common male sexual disorders. 2. Antioxidant action: Mucuna pruriens is a potent antioxidant and reduces oxidative damage to sperm by preventing disruption in the membrane integrity of spermatozoa. The actives isolated from Lactuca serriola—quercetin-3-O-beta-D-glucopyranoside, luteolin-7-O-beta-Dglucopyranoside, luteolin, quercetin, kaempferol, and 1beta, 13-dihydrolactucin—have potent antioxidant activity. 3. Other beneficial activities: Withania somnifera is a well-known adaptogen and provides restorative action in loss of sexual power. Lactuca serriola possesses sedative and nutritive properties, and is a rejuvenator. Tribulus terrestris, a tonic, is used to treat spermatorrhea and diseases of the genitourinary tract. Asteracantha longifolia is used in disorders of the genitourinary system. Svarnavanga is useful in gonorrhea and spermatorrhea. Argyreia speciosa is effective in gonorrheal infection, which affects fertility. Speman® (tablet)
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