T h e r a p e u t i c I n d e x 235 Septilin® (syrup, tablet) – Skin and soft tissue infections – Dental and periodontal infections – Ophthalmic infections – Bone and joint infections – Urinary tract infections • For early recovery in postoperative conditions • As an adjuvant to anti-infective therapy • Resistance to antibiotic therapy Dosage Syrup: Children: 1 to 2 teaspoonsful thrice daily. Adults: 2 teaspoonsful thrice daily. Tablet: Children: 1 tablet twice daily. Adults: 2 tablets twice daily till the symptoms are relieved, followed by 1 tablet twice daily as maintenance therapy. Adverse Effects No adverse effects have been reported. Contraindications Not recommended in early pregnancy. Drug Interactions No clinically significant drug interactions have been reported. Presentation Syrup: Pilfer-proof bottles of 200 mL. Tablet: Sealed packs of 60 tablets. Pharmacological Actions of Principal Ingredients 1. Anti-inflammatory action: Commiphora wightii and Glycyrrhiza glabra have potent anti-inflammatory activity. They downregulate the key inflammatory markers interferon (IFN)-γ, IL-12, TNF-α, IL-1β, and nitric oxide. Moringa pterygosperma has anti-inflammatory property. 2. Antimicrobial action: T cordifolia improves the phagocytic and intracellular bactericidal capacities of neutrophils. Glycyrrhizin from Glycyrrhiza glabra exhibits potent antiviral activity. Emblica officinalis has antibacterial property, especially against Escherichia coli, Klebsiella pneumoniae, Klebsiella ozaenae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Salmonella paratyphi A and B, and Serratia marcescens.
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