T h e r a p e u t i c I n d e x 234 Septilin® (syrup, tablet) Builds the body’s own defense mechanism Septilin, an Ayurvedic proprietary formulation, is recommended for the treatment and management of various infections and to prevent their recurrence. Septilin augments the host response, reduces inflammation, and corrects the underlying pathological features associated with recurrent infections. When co-prescribed with antibiotics, Septilin ensures faster recovery and prevents recurrence. Septilin is a valuable adjuvant in infection management and provides excellent short-term and long-term safety. Composition Each 5 mL of Septilin syrup contains: Pdr. Guggulu (Commiphora wightii).............................80 mg Exts. Maharasnadi kvatha..................................................30 mg Manjishtha (Rubia cordifolia). ................................15 mg Guduchi (Tinospora cordifolia)...............................14 mg Trikatu............................................................................13 mg Pushkara (Inula racemosa)......................................13 mg Amalaki (Emblica officinalis)..................................... 8 mg Yashti (Glycyrrhiza glabra)......................................... 6 mg Each Septilin tablet contains: Pdrs. Guggulu (Commiphora wightii)...........................0.324 g Shankha bhasma........................................................64 mg Exts. Maharasnadi kvatha............................................... 130 mg Guduchi (Tinospora cordifolia)...............................98 mg Manjishtha (Rubia cordifolia). ................................64 mg Amalaki (Emblica officinalis)...................................32 mg Shigru (Moringa pterygosperma)..........................32 mg Yashti (Glycyrrhiza glabra).......................................12 mg Clinical Pharmacology Septilin has anti-infective, anti-inflammatory, antimicrobial, host response–modulating, and antioxidant properties. Septilin modulates the inflammatory response during infections. Septilin reduces excessive production of the proinflammatory cytokines interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α, which are responsible for hyperinflammation and cellular/tissue damage. Septilin suppresses inflammation through downregulation of the PDE4B gene, a key regulator in the process of hyperinflammation. Septilin decreases eosinophil and IgE levels, and thus, alleviates allergy-like symptoms. Septilin augments the host response by enhancing phagocytosis through macrophage activation, increasing the polymorphonuclear cell level, promoting antibody production, and helping overcome infection. Septilin builds resistance to infection and helps manage chronic, recurrent infections. Septilin augments granulocyte–macrophage differentiation, natural killer cell activity, and antibody-dependent cytotoxicity. Septilin also augments the synthesis of erythropoietic and granulopoietic precursor cells. Indications • RT and ENT infections (tonsillitis, pharyngitis, bronchitis, sinusitis, and otitis media) • Other infections such as
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