T h e r a p e u t i c I n d e x 20 Clinical Pharmacology Bonnisan has carminative, antispasmodic, appetite-stimulating, anti-nauseating, mucoprotective and antisecretory, antioxidant, antimicrobial, anti-inflammatory, stomachic, hepatic-stimulant, hepatoprotective, mild laxative, and prebiotic actions. Bonnisan relieves the smooth muscle spasm associated with colic, protects the GI mucosa, removes entrapped gases from the GI tract, and offers protection against acute and chronic infections. Bonnisan helps infants and children gain weight adequately. Bonnisan helps restore the normal physiological functions of the digestive tract and ensures health and well-being. Indications • For the treatment of common digestive complaints in infants and children • As a daily health supplement in infants and children: – To prevent common digestive complaints – To promote healthy growth Dosage Drops: Infants up to 1 month: 5 to 10 drops (0.17 to 0.34 mL) thrice daily. 1 month to 6 months: 10 to 20 drops (0.34 to 0.68 mL) thrice daily. Liquid: Infants up to 1 month: ½ teaspoon (2.5 mL) thrice daily. 1 month to 6 months: 1 teaspoonful (5 mL) thrice daily. 6 months to 3 years: 2 teaspoonsful (10 mL) thrice daily. Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Drug Interactions No clinically significant drug interactions have been reported. Presentation Drops: Pilfer-proof bottle of 30 mL. Liquid: Pilfer-proof bottles of 100 mL and 200 mL. Pharmacological Actions of Principal Ingredients 1. Carminative action: Anethum graveolens, Piper longum, Cichorium intybus, Terminalia chebula, Elettaria cardamomum, and Kaempferia galanga have potent carminative actions that help relieve flatulence and prevent gaseous distension. Anethum graveolens is a well-known remedy for flatulence in children. 2. Antispasmodic action: Tinospora cordifolia, Capparis spinosa, Piper longum, Emblica officinalis, Cichorium intybus, Terminalia chebula, Elettaria cardamomum, Achillea millefolium, Boerhaavia diffusa, Fumaria officinalis, Embelia ribes, Foeniculum Bonnisan® (drops, liquid)
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