T h e r a p e u t i c I n d e x 213 Contraindications No known contraindications. Drug Interactions No clinically significant drug interactions have been reported. Presentation Pilfer-proof bottles of 100 mL and 200 mL. Pharmacological Actions of Principal Ingredients 1. Normalization of urinary pH: Hemidesmus indicus and Kshara parpati normalize urinary pH, possibly due to alterative and urinary supportive actions. 2. Anti-inflammatory and analgesic actions: Tribulus terrestris, Cyperus rotundus, Elettaria cardamomum, and Crataeva magna have remarkable anti-inflammatory and analgesic actions that reduce pain, as noticed during dysuria. Their anti-inflammatory action soothes the inflamed mucosa. 3. Antimicrobial action: Tribulus terrestris and Asparagus racemosus have antimicrobial action against common pathogens involved in UTI of varied etiology. 4. Diuretic action: Tribulus terrestris, Kshara parpati, Cyperus rotundus, and Vetiveria zizanioides have potent diuretic action that increases blood flow in the kidneys. This, in turn, increases glomerular filtration rate (GFR), and hence the output of urine. This process increases the amount of water excreted through urination, but it does not increase elimination of electrolytes such as sodium, chloride, and bicarbonate, as noticed with other diuretics. This action certainly helps in the pathological states like pyelonephritis, urethritis and cystitis, and also prevents urolithiasis that results from the stasis of urine in kidneys. 5. Renoprotective action: Hemidesmus indicus has renoprotective effect, which protects against chemically-induced nephrotoxicity. Asparagus racemosus elevates urinary concentration of magnesium, which is considered one of the inhibitors of crystallization. Tribulus terrestris has renoprotective action due to its enhanced chloride and creatinine clearance from the body. 6. Antioxidant action: Hemidesmus indicus and Asparagus racemosus are potent antioxidants, which protect the genitourinary system from oxidative tissue damage. 7. Other beneficial activities: Trikatu (Piper nigrum, Piper longum, and Zingiber officinale) increases the bioavailability of other drugs either by promoting rapid absorption from the gastrointestinal tract, or by protecting the drug from being metabolized/oxidized in its first passage through the liver after being absorbed, or by a combination of both the mechanisms. Renalka® (syrup)
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