T h e r a p e u t i c I n d e x 18 Adverse Effects No clinically significant adverse effects have been reported. Contraindications No known contraindications. Precautions • Application should be limited to an area no larger than the face and neck, or hands and arms. • To be used exclusively for external application. • Contact with eyes or open wounds to be avoided. Presentation SeamLess tube of 30 mL. Pharmacological Actions of Principal Ingredients 1. Melanin synthesis-inhibitory action: Glabridin in Glycyrrhiza glabra has an inhibitory effect on pigmentation by inhibiting melanocyte tyrosinase activity without causing cytotoxicity. Gallic acid in Bombax malabaricum and Rheum emodi has excellent tyrosinase-inhibitory and antioxidant activities, which inhibit melanin production. The phenols in Vateria indica and the oil in Prunus amygdalus are natural antioxidants that help in decreasing melanin synthesis. They have proven activity in inhibiting melanogenesis. 2. Anti-inflammatory action: The anti-inflammatory property of glycyrrhizin in Glycyrrhiza glabra helps in the management of hyperpigmentation due to recurrent inflammatory conditions such as acne. 3. Skin-protective and complexion-improving actions: Glycyrrhizin in Glycyrrhiza glabra significantly inhibits photoaging by reducing reactive oxygen species (ROS), nuclear factor kappa B (NF-kB), cytochrome c, and caspase-3 levels. It inhibits the hyaluronidase enzyme in ultraviolet B (UVB) irradiation-induced photoaging in human dermal fibroblasts. The oil of Prunus amygdalus smooths and rejuvenates the skin, and is effective in improving skin complexion and tone. Bleminor® (cream)
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