T h e r a p e u t i c I n d e x 136 NAFLD: DS tablet: 1 to 2 tablets b.i.d Supportive treatment for liver injury due to chemotherapy and radiotherapy: DS syrup/DS tablet: 1 teaspoonful (5 mL) b.i.d./1 tablet b.i.d. for 3 months Adverse Effects Liv.52 is not known to have any significant adverse reaction or serious adverse event if taken as per the prescribed dosage. Contraindications No known contraindications. Drug Interactions No clinically significant drug interactions have been reported. Presentation Drops: Pilfer-proof bottles of 60 mL and 100 mL. Syrup: Pilfer-proof bottles of 100 mL and 200 mL. Tablet: Sealed pack of 100 tablets. DS syrup: Pilfer-proof bottles of 100 mL and 200 mL. DS tablet: Sealed pack of 60 tablets. Pharmacological Actions of Principal Ingredients 1. Hepatoprotective action: The p-methoxy benzoic acid from Capparis spinosa has potent hepatoprotective activity against chemically-induced hepatotoxicity, and prevents elevation of malondialdehyde levels (plasma and hepatic) and enzyme levels [alanine transaminase (ALT) and aspartate transaminase (AST)]. Capparis spinosa improves the functional efficiency of the liver and spleen, with protective action on the histological architecture of the liver, and a salutary effect on liver glycogen and serum proteins. Cichorium intybus protects the liver against alcohol toxicity. It increases circulating leukocytes, splenic plaque-forming cells, hemagglutination titers, secondary IgG antibody response, phagocytic activity, natural killer cell activity, cell proliferation, and interferon-gamma (IFN-g) secretion. The hepatoprotective activity of Cichorium intybus suppresses the oxidative degradation of DNA in tissue debris. Solanum nigrum has hepatoprotective activity against chemically-induced hepatic damage. It decreases the elevated LFT biochemical parameters [ALT, AST, alkaline phosphatase (ALP), and total bilirubin (TB)], and increases the activities of aminopyrine N-demethylase, uridine diphosphate, glucuronyl transferase, and glutathione S-transferase. Cassia occidentalis has significant hepatoprotective effect in chemically-induced liver damage. It modulates hepatic enzymes to provide hepatoprotection. Achillea millefolium is beneficial in chronic hepatitis, chronic hepatocholecystitis, angiocholitis, and has anti-hepatoma activity. Liv.52® (drops, syrup, tablet, DS syrup, DS tablet)
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