T h e r a p e u t i c I n d e x 134 Each Liv.52 tablet contains: Pdrs. Himsra (Capparis spinosa). .....................................65 mg Arjuna (Terminalia arjuna).................................... 32 mg Kasani (Cichorium intybus).....................................65 mg Kasamarda (Cassia occidentalis)......................... 16 mg Mandura bhasma.......................................................33 mg Biranjasipha (Achillea millefolium)..................... 16 mg Kakamachi (Solanum nigrum)...............................32 mg Jhavuka (Tamarix gallica). .................................... 16 mg Processed in Bhringaraja (Eclipta alba), Bhumyaamalaki (Phyllanthus amarus), Punarnava (Boerhaavia diffusa), Guduchi (Tinospora cordifolia), Daruharidra (Berberis aristata), Mulaka (Raphanus sativus), Amalaki (Emblica officinalis), Chitraka (Plumbago zeylanica), Vidanga (Embelia ribes), Haritaki (Terminalia chebula), and Parpata (Fumaria officinalis). Each 5 mL of Liv.52 DS syrup contains: Exts. Himsra (Capparis spinosa). .....................................68 mg Kasamarda (Cassia occidentalis)......................... 16 mg Kasani (Cichorium intybus).....................................68 mg Biranjasipha (Achillea millefolium)..................... 16 mg Kakamachi (Solanum nigrum)...............................32 mg Jhavuka (Tamarix gallica). .................................... 16 mg Arjuna (Terminalia arjuna). ....................................32 mg Processed in Bhringaraja (Eclipta alba), Bhumyaamalaki (Phyllanthus amarus), Punarnava (Boerhaavia diffusa), Guduchi (Tinospora cordifolia), Daruharidra (Berberis aristata), Mulaka (Raphanus sativus), Amalaki (Emblica officinalis), Chitraka (Plumbago zeylanica), Vidanga (Embelia ribes), Haritaki (Terminalia chebula), and Parpata (Fumaria officinalis). Each Liv.52 DS tablet contains: Pdrs. Himsra (Capparis spinosa). .................................. 130 mg Arjuna (Terminalia arjuna).................................... 64 mg Kasani (Cichorium intybus).................................. 130 mg Kasamarda (Cassia occidentalis)......................... 32 mg Mandura bhasma.......................................................66 mg Biranjasipha (Achillea millefolium)..................... 32 mg Kakamachi (Solanum nigrum)...............................64 mg Jhavuka (Tamarix gallica). .................................... 32 mg Processed in Bhringaraja (Eclipta alba), Bhumyaamalaki (Phyllanthus amarus), Punarnava (Boerhaavia diffusa), Guduchi (Tinospora cordifolia), Daruharidra (Berberis aristata), Mulaka (Raphanus sativus), Amalaki (Emblica officinalis), Chitraka (Plumbago zeylanica), Vidanga (Embelia ribes), Haritaki (Terminalia chebula), and Parpata (Fumaria officinalis). Clinical Pharmacology Liv.52 has hepatoprotective, antioxidant, antimicrobial, antiviral, and anti-inflammatory actions. Liv.52 restores the metabolic efficiency of the liver by protecting the hepatic parenchyma and promoting hepatocellular regeneration. The antiperoxidative activity of Liv.52 prevents the loss of functional integrity of cell membranes, maintains the cytochrome P450 enzyme system, does not inhibit the major isoforms of cytochrome P450 (which indicates that Liv.52 does not pose any drug interaction risk), shortens the disease recovery period, and ensures early restoration of hepatic functions in infectious hepatitis. Liv.52 offers protection against ALD by facilitating a rapid elimination of acetaldehyde, the toxic intermediate metabolite of alcohol metabolism. Liv.52 attenuates ethanol-induced expression of tumor necrosis factor (TNF)-α, and thereby abrogates inflammation in the liver cells. Liv.52 modulates the lipotropic activity in chronic alcoholism, and prevents fatty infiltration of the liver. In NAFLD/MAFLD, Liv.52 reduces de novo lipogenesis, which is a pivotal process implicated in hepatic fat build-up. Liv.52 enhances mitochondrial function and augments fatty acid oxidation within the hepatocytes, collectively Liv.52® (drops, syrup, tablet, DS syrup, DS tablet)
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