T h e r a p e u t i c I n d e x 11 Clinical Pharmacology Abana reduces the sensitivity of the heart to adrenergic stimulation and stabilizes blood pressure. Abana regulates serum lipids by lowering cholesterol and triglyceride (TG) and low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) levels and restores the cardioprotective high-density lipoprotein (HDL) level. Abana also reduces platelet aggregation. Abana improves the contractility of the heart by exerting a positive inotropic action. Thus, Abana produces cardioprotection. Abana offers long-term protection against CVDs through antihypertensive, lipid-normalizing, platelet aggregationinhibitory, thrombin-inhibitory, anticoagulant, myocardial/cardioprotective, coronary vasodilatory (antianginal), antioxidant, proinflammatory mediator-inhibitory, adaptogenic, anxiolytic, and diuretic actions. Indications • Mild to moderate hypertension • Dyslipidemia • Cardiovascular and cerebrovascular conditions requiring inhibition of platelet aggregation • As an adjuvant in the therapy of angina, and in patients with cardiac risk factors Dosage 2 tablets twice daily, followed by 1 tablet twice daily as maintenance dose. Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Special Precautions It is advisable to use Abana under medical supervision if the pre-existing medical conditions are long-standing and refractory to other modern medications. Drug Interactions No clinically significant drug interactions have been reported. Presentation Sealed pack of 60 tablets. Pharmacological Actions of Principal Ingredients 1. Antihypertensive action: Abana reduces the sensitivity of the heart to adrenergic stimulation and stabilizes the raised systolic and diastolic blood pressure. Terminalia arjuna has antihypertensive action that helps to stabilize blood pressure. Withania somnifera and Commiphora wightii are beneficial in hypertension. Boerhaavia diffusa, Cinnamomum cassia, and Aloe vera have antihypertensive action. Nardostachys jatamansi and Acorus calamus have antihypertensive and cardiotonic activities. Zingiber officinale is useful in reducing palpitations. Foeniculum vulgare exerts antihypertensive action through its diuretic properties. Daucus carota exerts antihypertensive action. Abana® (tablet)
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