T h e r a p e u t i c I n d e x 8 Directions for Use Wet the affected area, apply the soap generously, gently work up lather with a circular motion, and rinse with water. To be used twice daily. Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Special Precautions • Should not be used by patients having hypersensitivity to any of the ingredients • Children under 6 years of age should use under adult supervision • To be used only for external application. Presentation Pack of 75 g soap. Pharmacological Actions of Principal Ingredients 1. Antibacterial action: Pongamia pinnata (synonym: Pongamia glabra) and Azadirachta indica seed oils have bactericidal activity against various strains of pathogenic bacteria, and this activity is mainly due to inhibition of cell-membrane synthesis in the bacteria. The essential oils of Citrus limon, Ocimum basilicum, and Vetiveria zizanioides show strong antibacterial activity against common skin-colonizing bacteria. 2. Antifungal and antidermatophytic actions: A clinical study proves that Aactaril soap is an effective agent in treating superficial fungal infections like Tinea versicolor and cutaneous candidiasis including intertrigo, without any side effects and contraindications. Azadirachta indica has good anticandidal activity and shows excellent results in Pityriasis versicolor (yeast) infection of the skin. It also possesses fungicidal activity against tinea capitis, tinea corporis, tinea cruris, tinea pedis, and tinea unguium. The essential oil of Citrus limon peel exhibits fungitoxicity against Epidermophyton floccosum, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum, and Trichophyton tonsurans strains, which are common among dermatophytic skin infections. The essential oil of Ocimum basilicum contains linalool, its main component, which shows good antifungal activity. Vetiveria zizanioides exhibits promising antimicrobial potential, especially against Candida albicans. 3. Anti-inflammatory action: The alpha-linolenic acid, an omega-3 fatty acid found abundantly in the oil of Linum usitatissimum seeds, exerts potent anti-inflammatory activity through inhibiting key proinflammatory cytokines, viz., interleukin (IL)-6, IL-8, IL-1β and TNF-α, and by downregulating inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) via nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinase pathways. Aactaril® (soap)
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