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T h e r a p e u t i c I n d e x 1 Listening to Nature The future of medicine increasingly resembles a science fiction movie—therapy, stem cell-based treatments, assistive technologies, growing a human heart, using robotics to enhance patient care, and even developing a transplantable human kidney from 3D printing! The advances in modern medicine are mind-boggling! In this age of revolutionary, path-breaking treatments, is there room for herbal medicine? The answer quite simply is – yes. The quest for better health care is leading medicine down different paths, and all of them converge at a common point—effective treatments to improve the quality of life for patients. Increasingly, the medical fraternity is realizing that no single system of medicine can provide all the answers. This has sparked engaging conversations across disciplines, and more doctors are receptive to new treatments, new ideas, and new approaches. In the US and other parts of the western world, “Integrative Medicine,” a system of medicine that combines the best of conventional and traditional therapies, is gaining credibility. There is one important caveat. The guiding principle of integrative medicine is that nonconventional therapies must also be validated by research and clinical data. Interestingly, way back in 1930, when Himalaya’s founder, Mr M Manal, set up the company, he was speaking the language of integrative medicine. He had immense faith in the enduring relevance of Ayurveda, India’s 5000-year-old system of medicine. But, Mr Manal knew that wider acceptance for Ayurveda would come only when its safety and efficacy were scientifically established. He had a clear vision for Himalaya—contemporize Ayurveda through research and make it accessible to modern society. More than 90 years later, we continue to live by this philosophy. Himalaya’s products conform to allopathic protocols of drug development, from toxicity and stability studies to phase I to phase IV clinical studies. Each product undergoes an average of 6 to 8 years of research, which includes several clinical studies at leading hospitals. The results are published in Indian and international peer-reviewed medical journals. Quality is an obsession at Himalaya, and we monitor it from the stage of herb cultivation to the finished product. This includes strict compliance with international guidelines for Good Agricultural Practices (GAP) and Good Harvesting Practices (GHP). We are an ISO 9001:2008 certified company, and follow Good Clinical Practices (GCP), Good Laboratory Practices (GLP), and current Good Manufacturing Practices (cGMP). Himalaya’s scientists push the boundaries of herbal medicine and research on drugs for various health care segments such as renal health and cancer therapy and products for children’s and women’s nutrition and general wellness. These are not easy goals. Expecting herbs to do the job of chemical molecules is most definitely a challenge. Listening to nature requires a great deal of patience. However, we do have our eureka moments. Our launches Immusante and Oro-T Oral Rinse (oncology segment), Quista range of products (nutrition segment), Rumalaya Active Spray (pain management), and Gasex Fizz
T h e r a p e u t i c I n d e x 2 (general wellness) demonstrate the perseverant efforts. Adding a new dimension to our diverse product portfolio are the quick mouth dissolving tablets (MDTs), categorized under the Q-DEE range. These MDTs are specially formulated to provide quick relief from common complaints including acidity, cramps, symptoms of flu and common cold, indigestion, and nausea. This edition of the Therapeutic Index has been updated with information on our recent product innovations. With support from the medical community, Himalaya is committed to integrating evidence-based Ayurveda into contemporary health care so people around the world can enjoy healthier, happier lives.
T h e r a p e u t i c I n d e x 3 CONTENTS Aactaril (soap)..............................................................................................................................................7 Abana (tablet)............................................................................................................................................. 10 Althea (lotion)............................................................................................................................................ 14 Bleminor (cream)...................................................................................................................................... 17 Bonnisan (drops, liquid)......................................................................................................................... 19 Bonnispaz (drops).................................................................................................................................... 23 Bresol (syrup, tablet). .............................................................................................................................. 25 Bresol-NS Saline Nasal Solution (drops/spray)..................................................................... 28 Clarina (anti-acne face wash gel)........................................................................................................ 33 Clarina (anti-acne cream)....................................................................................................................... 35 Confido (tablet).......................................................................................................................................... 37 Cystone (syrup). ........................................................................................................................................ 39 Cystone (tablet)......................................................................................................................................... 42 Cystone forte (tablet). .......................................................................................................................... 46 Cystone-SF (liquid).................................................................................................................................. 49 Diabecon (tablet, DS tablet). ................................................................................................................ 52 Diarex (syrup, tablet)............................................................................................................................... 59 Evecare (capsule, syrup)........................................................................................................................ 62 Evecare forte (liquid, tablet). ..............................................................................66 Florasante (capsule) .............................................................................................68 Gasex (syrup).............................................................................................................................................. 70 Gasex (tablet)............................................................................................................................................. 73 Geriforte (syrup, tablet)......................................................................................................................... 76 Hairzone (solution). ................................................................................................................................. 80 Heal Lip (medicated lip balm). ............................................................................................................ 82 Herbolax (capsule, tablet). .................................................................................................................... 84 Himcocid-SF (suspension).................................................................................................................... 87 Himcolin (gel)............................................................................................................................................. 89 Himcospaz (soft capsule)...................................................................................................................... 93 Himplasia (tablet)..................................................................................................................................... 95 HiOra (toothpaste)................................................................................................................................. 98 HiOra (mouthwash – regular)........................................................................................................101 HiOra-GA (gel).........................................................................................................................................103 HiOra-Pain Gel (gel)............................................................................................................................105 HiOra-K (toothpaste)...........................................................................................................................107
T h e r a p e u t i c I n d e x 4 HiOra-K (mouthwash).........................................................................................................................109 HiOra-SG (gel).........................................................................................................................................111 Immusante (tablet)...............................................................................................................................113 Koflet (lozenge)........................................................................................................................................115 Koflet (syrup). ...........................................................................................................................................117 Koflet-H (lozenge)...................................................................................................................................120 Koflet-EX (linctus)...................................................................................................................................122 Koflet-SF (linctus)...................................................................................................................................125 Koflet-SF (lozenge). ...............................................................................................................................128 Liv.52 (drops, syrup, tablet, DS syrup, DS tablet).........................................................................133 Liv.52 HB (capsule).................................................................................................................................139 Lukol (syrup)..............................................................................................................................................141 Lukol (tablet).............................................................................................................................................144 Menosan (tablet). ...................................................................................................................................149 Mentat [syrup, tablet, DS syrup (sugar-free)]................................................................................152 OphthaCare (eye drops). .....................................................................................................................159 Oro-T Oral Rinse (liquid).....................................................................................................................162 Oxitard (capsule).....................................................................................................................................164 Pilex (tablet)..............................................................................................................................................168 Pilex forte (ointment)..........................................................................................................................170 Pilex forte (tablet). ...............................................................................................................................172 Platenza (syrup, tablet)........................................................................................................................177 PureHands ADVANCED (hand rub, spray).........................................................................................180 Purim (tablet)............................................................................................................................................182 Acidity (mouth dissolving tablet).....................................................................................187 Cramps (mouth dissolving tablet)....................................................................................189 Immunity (mouth dissolving tablet). ..............................................................................191 Indigestion (mouth dissolving tablet)...........................................................................193 Nausea (mouth dissolving tablet)....................................................................................195 ........................................................................................................................................197 . ............................................................................................................................................201 ............................................................................................................................................204 . ............................................................................................................................................208 Renalka (syrup).......................................................................................................................................212 Reosto (tablet).........................................................................................................................................214 Rumalaya Active Spray (Spray).....................................................................................................217 Rumalaya (gel). .......................................................................................................................................220 Contents PRO
T h e r a p e u t i c I n d e x 5 Note: The indications, dosage, and special precautions of the products mentioned here are based on the existing evidence. However, doctors may prescribe the products based on their discretion. Rumalaya (liniment)..............................................................................................................................225 Rumalaya (tablet)...................................................................................................................................228 Rumalaya forte (tablet)......................................................................................................................231 Septilin (syrup, tablet). .........................................................................................................................234 Serpina (tablet)........................................................................................................................................239 Speman (tablet).......................................................................................................................................241 Styplon (tablet)........................................................................................................................................243 Talekt (syrup, tablet). .............................................................................................................................245 Tentex forte (tablet).............................................................................................................................248 Tentex Royal (capsule)........................................................................................................................251 Vegecort (cream). ..................................................................................................................................254 V-Gel (gel)...................................................................................................................................................257 Contents
T h e r a p e u t i c I n d e x 6
T h e r a p e u t i c I n d e x 7 Composition Each gram of Aactaril soap contains: Oils Barbari (Ocimum basilicum)................................... 12 mg Jambira (Citrus limon).................................................4 mg Ushira (Vetiveria zizanioides)....................................4 mg Draksha (Vitis vinifera)............................................ 3.3 mg Atasi (Linum usitatissimum).................................. 2.3 mg Aactaril® (soap) Medicated cleansing soap for bacterial and fungal skin infections Aactaril is a natural, medicated cleansing soap, recommended for the management of bacterial and fungal skin infections. Aactaril soap acts as an effective adjuvant to the standard medical care for skin infections. Aactaril is a grade 1 soap, with a high TFM (Total Fatty Matter) of 76%. Enriched with natural essential oils, Aactaril soap is gentle, non-irritating, and dermatologically tested. Aactaril soap is skin-friendly, as it is free from harsh chemicals like SLS (Sodium Lauryl Sulfate), synthetic preservatives, colors, and fragrances (e.g., phthalates). Aactaril soap is suitable for all skin types including dry and sensitive skin. Aactaril soap is ideal for everyday use on the hands, face, and body. Vatada (Prunus amygdalus)................................... 2.2 mg Nimba (Azadirachta indica)...................................1.1 mg Tuvarak (Hydnocarpus pentandrus)..................0.55 mg Karanja (Pongamia glabra)..................................0.55 mg Clinical Pharmacology Aactaril medicated soap helps to alleviate the signs and symptoms of bacterial and fungal skin infections by virtue of its antibacterial, antifungal, antidermatophytic, anti-inflammatory, and moisturizing actions. The anti-inflammatory properties of Aactaril soap help soothe the inflamed skin and restore skin health. Aactaril provides relief from itching, scaling, cracking, burning, redness, soreness, and irritation. Aactaril reduces the risk of recurrent skin infections. Aactaril soap has a mild cleansing action. It maintains the natural skin flora and does not cause dryness. The rich natural oil content in Aactaril soap prevents excess removal of important lipids and proteins present in the skin, leaving it soft, supple and healthy. Indications As an adjuvant in the treatment of: • Bacterial skin infections: Folliculitis, cellulitis, impetigo, furuncles, and carbuncles • Fungal skin infections: Tinea versicolor and candidal infections • For the management of recurrent skin infections
T h e r a p e u t i c I n d e x 8 Directions for Use Wet the affected area, apply the soap generously, gently work up lather with a circular motion, and rinse with water. To be used twice daily. Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Special Precautions • Should not be used by patients having hypersensitivity to any of the ingredients • Children under 6 years of age should use under adult supervision • To be used only for external application. Presentation Pack of 75 g soap. Pharmacological Actions of Principal Ingredients 1. Antibacterial action: Pongamia pinnata (synonym: Pongamia glabra) and Azadirachta indica seed oils have bactericidal activity against various strains of pathogenic bacteria, and this activity is mainly due to inhibition of cell-membrane synthesis in the bacteria. The essential oils of Citrus limon, Ocimum basilicum, and Vetiveria zizanioides show strong antibacterial activity against common skin-colonizing bacteria. 2. Antifungal and antidermatophytic actions: A clinical study proves that Aactaril soap is an effective agent in treating superficial fungal infections like Tinea versicolor and cutaneous candidiasis including intertrigo, without any side effects and contraindications. Azadirachta indica has good anticandidal activity and shows excellent results in Pityriasis versicolor (yeast) infection of the skin. It also possesses fungicidal activity against tinea capitis, tinea corporis, tinea cruris, tinea pedis, and tinea unguium. The essential oil of Citrus limon peel exhibits fungitoxicity against Epidermophyton floccosum, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum, and Trichophyton tonsurans strains, which are common among dermatophytic skin infections. The essential oil of Ocimum basilicum contains linalool, its main component, which shows good antifungal activity. Vetiveria zizanioides exhibits promising antimicrobial potential, especially against Candida albicans. 3. Anti-inflammatory action: The alpha-linolenic acid, an omega-3 fatty acid found abundantly in the oil of Linum usitatissimum seeds, exerts potent anti-inflammatory activity through inhibiting key proinflammatory cytokines, viz., interleukin (IL)-6, IL-8, IL-1β and TNF-α, and by downregulating inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) via nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinase pathways. Aactaril® (soap)
T h e r a p e u t i c I n d e x 9 Nimbidin, the major active principle in Azadirachta indica seed oil, helps reduce inflammation mainly by inhibiting nitric oxide (NO) production (via inhibiting iNOS), prostaglandin E2 (PGE2) production, and attenuating neutrophil degranulation. Hydnocarpus pentandrus seed oil helps in soothing dry, inflamed, and itchy skin. The oil is extensively used in traditional medicine for inflammatory skin conditions. The Vetiveria zizanioides essential oil may suppress the inflammatory response including NO production and regulation of inflammatory cytokines. The volatile oils isolated from Ocimum basilicum show topical anti-inflammatory activity, and also have been reported to possess significant antifungal and antibacterial activities. The essential oil of Citrus limon is rich in limonene, a monoterpene, which has a potent anti-inflammatory effect, and is commonly used for both therapeutic and cosmetic purposes. 4. Moisturizing action: The emollient properties of long-chain fatty acids (e.g., stearic acid, linoleic acid, linolenic acid, and oleic acid) found in Linum usitatissimum, Pongamia glabra, Vitis vinifera, and Prunus amygdalus oils help moisturize by filling up the spaces between skin flakes, reduce transepidermal water loss (TEWL), and enhance epidermal barrier function, thus helping to maintain skin hydration and integrity. Aactaril® (soap)
T h e r a p e u t i c I n d e x 10 Processed in Abresham, Gojiha (Onosma bracteatum), Amalaki (Emblica officinalis), Mandukaparni (Centella asiatica), Satapatri (Rosa damascena), Kamala (Nelumbium speciosum), Dadima (Punica granatum), Sevam (Pyrus malus), Shankhapushpi (Convolvulus pluricaulis), Shatavari (Asparagus racemosus), Kumari (Aloe vera), Badranj boya (Nepeta hindostana), Tulasi (Ocimum sanctum), Mishreya (Foeniculum vulgare), Ushira (Vetiveria zizanioides), and Garijara (Daucus carota). Composition Each Abana tablet contains: Exts. Arjuna (Terminalia arjuna). ....................................30 mg Ashvagandha (Withania somnifera)................... 20 mg Badranj boya (Nepeta hindostana)...................... 20 mg Dashamoola................................................................ 20 mg Guduchi (Tinospora cordifolia). ............................ 10 mg Amalaki (Emblica officinalis).................................. 10 mg Haritaki (Terminalia chebula). ............................... 10 mg Bhringaraja (Eclipta alba) ....................................... 10 mg Yashti (Glycyrrhiza glabra)...................................... 10 mg Shatavari (Asparagus racemosus)......................... 10 mg Punarnava (Boerhaavia diffusa)............................ 10 mg Pdrs. Guggulu (Commiphora wightii)............................ 30 mg Shilajeet........................................................................ 20 mg Mandukaparni (Centella asiatica)........................ 10 mg Shankhapushpi (Convolvulus pluricaulis).......... 10 mg Tulasi (Ocimum sanctum). ...................................... 10 mg Jatamansi (Nardostachys jatamansi).................. 10 mg Pippali (Piper longum).............................................. 10 mg Yavani (Carum copticum)........................................ 10 mg Sunthi (Zingiber officinale). .................................... 10 mg Nagapashana bhasma. ........................................... 10 mg Shankha bhasma....................................................... 10 mg Makaradhvaja............................................................. 10 mg Musta (Cyperus rotundus)..........................................5 mg Vacha (Acorus calamus)..............................................5 mg Vidanga (Embelia ribes)..............................................5 mg Lavanga (Syzygium aromaticum)............................5 mg Jyotishmati (Celastrus paniculatus)........................5 mg Chandana (Santalum album)...................................5 mg Sukshmaila (Elettaria cardamomum). ...................5 mg Mishreya (Foeniculum vulgare)................................5 mg Satapatrika (Rosa centifolia).....................................5 mg Tvak patra (Cinnamomum cassia)...........................5 mg Abhraka bhasma..........................................................5 mg Mukta pishti...................................................................5 mg Akika pishti.....................................................................5 mg Vyomashma pishti.......................................................5 mg Manikya pishti...............................................................5 mg Pravala pishti. ................................................................5 mg Kumkuma (Crocus sativus)........................................2 mg Abana® (tablet) The multifaceted cardioprotective Abana is recommended for the long-term management of cardiovascular diseases (CVDs). Abana offers multifold benefits: Abana possesses antihypertensive property, corrects dyslipidemia, and exhibits antiplatelet action that reduces platelet adhesion and aggregation in cases of coronary heart disease and hypertension. Thus, Abana is effective and safe for the long-term management of CVDs.
T h e r a p e u t i c I n d e x 11 Clinical Pharmacology Abana reduces the sensitivity of the heart to adrenergic stimulation and stabilizes blood pressure. Abana regulates serum lipids by lowering cholesterol and triglyceride (TG) and low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) levels and restores the cardioprotective high-density lipoprotein (HDL) level. Abana also reduces platelet aggregation. Abana improves the contractility of the heart by exerting a positive inotropic action. Thus, Abana produces cardioprotection. Abana offers long-term protection against CVDs through antihypertensive, lipid-normalizing, platelet aggregationinhibitory, thrombin-inhibitory, anticoagulant, myocardial/cardioprotective, coronary vasodilatory (antianginal), antioxidant, proinflammatory mediator-inhibitory, adaptogenic, anxiolytic, and diuretic actions. Indications • Mild to moderate hypertension • Dyslipidemia • Cardiovascular and cerebrovascular conditions requiring inhibition of platelet aggregation • As an adjuvant in the therapy of angina, and in patients with cardiac risk factors Dosage 2 tablets twice daily, followed by 1 tablet twice daily as maintenance dose. Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Special Precautions It is advisable to use Abana under medical supervision if the pre-existing medical conditions are long-standing and refractory to other modern medications. Drug Interactions No clinically significant drug interactions have been reported. Presentation Sealed pack of 60 tablets. Pharmacological Actions of Principal Ingredients 1. Antihypertensive action: Abana reduces the sensitivity of the heart to adrenergic stimulation and stabilizes the raised systolic and diastolic blood pressure. Terminalia arjuna has antihypertensive action that helps to stabilize blood pressure. Withania somnifera and Commiphora wightii are beneficial in hypertension. Boerhaavia diffusa, Cinnamomum cassia, and Aloe vera have antihypertensive action. Nardostachys jatamansi and Acorus calamus have antihypertensive and cardiotonic activities. Zingiber officinale is useful in reducing palpitations. Foeniculum vulgare exerts antihypertensive action through its diuretic properties. Daucus carota exerts antihypertensive action. Abana® (tablet)
T h e r a p e u t i c I n d e x 12 2. Lipid-normalizing action: Abana effectively reduces low-density lipoprotein cholesterol (LDLc), very low-density lipoprotein cholesterol (VLDLc) and triglyceride (TG) levels, and increases the cardioprotective high-density lipoprotein cholesterol (HDLc) levels. Terminalia arjuna has hypolipidemic activity that reduces total cholesterol (TC) and TGs in atherosclerosis. Withania somnifera has antihypercholesterolemic action that attenuates the development of atherosclerotic lesions. Tinospora cordifolia reduces serum and tissue cholesterol, phospholipids, and free fatty acids (FFAs). Emblica officinalis reduces serum cholesterol, TG, phospholipid, LDL and tissue lipid levels, with regression of aortic plaque. Its hypolipidemic action inhibits synthesis of, and degrades and excretes cholesterol and phospholipids. Terminalia chebula has significant antihypercholesterolemic action. Ocimum sanctum and Crocus sativus have antihypercholesterolemic action. Glycyrrhiza glabra has hypocholesterolemic activity. It reduces the plasma and hepatic total lipid, cholesterol, TG, LDLc and VLDLc levels, and increases HDLc levels. It accelerates cholesterol, neutral sterol and bile acid elimination through fecal matter, with increased hepatic bile acid production. Also, it improves the hepatic antioxidant enzymes by increasing ascorbic acid. Boerhaavia diffusa reduces serum and tissue cholesterol, FFAs, phospholipids, and TGs. Commiphora wightii lowers plasma TC, TG, FFA, and phospholipid levels through liver lipolytic activity, increased fecal bile acid excretion, and inhibition of hepatic cholesterol biosynthesis and lipid peroxidation. Nardostachys jatamansi has antihyperlipidemic action. Piper longum and Zingiber officinale are potent inhibitors of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase, and thus reduce cholesterol in the system. Zingiber officinale reduces plasma TGs, cholesterol, LDLc, and VLDLc. Its hypolipidemic action decreases hepatic cholesterol biosynthesis and reduces LDL peroxidation. Acorus calamus has significant hypolipidemic action. Pyrus malus has hypolipidemic action. Embelia ribes has antidyslipidemic action that decreases serum TC and TGs, and increases HDLc. Foeniculum vulgare has antidyslipidemic action that inhibits lipid peroxidation and increases HDLc. Punica granatum normalizes abnormal cardiac lipid metabolism by activating peroxisome proliferator-activated receptor-alpha (PPARa) and lowering circulating lipids. Aloe vera reduces hepatic transaminases, plasma and tissue cholesterol, TGs, FFAs, and phospholipids. It normalizes the decreased plasma levels of HDLc. Daucus carota modifies cholesterol absorption and bile acid excretion. 3. Platelet aggregation–inhibitory action: Abana reduces abnormal platelet adhesion and aggregation, and hence, is beneficial in cardiovascular and cerebrovascular conditions requiring inhibition of platelet aggregation. Terminalia arjuna and Syzygium aromaticum have potent platelet aggregation–inhibiting activity. Gingerols in Zingiber officinale prevent platelet aggregation due to inhibition of thromboxane formation. 4. Thrombin-inhibitory action: Glycyrrhiza glabra has remarkable thrombin-inhibitory action. Zingiber officinale has antithrombotic action. Abana® (tablet)
T h e r a p e u t i c I n d e x 13 5. Anticoagulant action: Withania somnifera has anticoagulant activity. 6. Myocardial/Cardioprotective action: Terminalia arjuna, Acorus calamus, Withania somnifera, Terminalia chebula, Nardostachys jatamansi, and Ocimum sanctum minimize ischemic injury to the myocardium. Aglycones in Terminalia arjuna are responsible for positive inotropic effect that improves cardiac pumping and myocardial performance. 7. Coronary vasodilatory (antianginal) action: Terminalia arjuna has coronary vasodilatory (antianginal) action. 8. Antioxidant action: Terminalia arjuna, Withania somnifera, Tinospora cordifolia, Terminalia chebula, Glycyrrhiza glabra, Asparagus racemosus, Commiphora wightii, Centella asiatica, Ocimum sanctum, Nardostachys jatamansi, Piper longum, Zingiber officinale, Acorus calamus, Syzygium aromaticum, and Foeniculum vulgare are antioxidants that prevent oxidative damage (which leads to endothelial dysfunction) in CVDs. Emblica officinalis, the richest natural source of vitamin C and a powerful antioxidant, acts as a natural cardioprotective by reducing oxidative stress in the heart. 9. Inhibition of proinflammatory mediators: Punica granatum acts as nuclear factor kappa B (NF-kB) inhibitor in vascular endothelial cells and thereby inhibits plaque formation. 10. Adaptogenic action: Stress plays a major role in the development and exacerbation of CVDs, and adaptogens are the drugs of choice for the management of stress-related disorders. They increase the resistance against multiple stressors (physical, chemical, and biological), and have a normalizing influence without disturbing the normal physiological functions. Reduction of stressors results in normalization of cardiac activities, thus producing a cardioprotective effect. Withania somnifera has anti-stress and adaptogenic activities. Asparagus racemosus, Terminalia chebula, Emblica officinalis, Piper longum, and Ocimum sanctum have potent adaptogenic actions. 11. Anxiolytic action: Anxiety is an important stress-inducer and a known risk factor for CVDs. Centella asiatica is a well-known tranquilizer and nervine tonic. Glycyrrhiza glabra has remarkable anxiolytic action. Convolvulus pluricaulis has tranquilizing and anxiolytic effects. Nardostachys jatamansi has anxiolytic and tranquilizing properties, and is beneficial in patients with nervousness and palpitation. 12. Diuretic action: Withania somnifera, Boerhaavia diffusa, and Terminalia chebula have diuretic actions that reduce cardiac load, normalize the blood pressure, and prevent CVDs. Abana® (tablet)
T h e r a p e u t i c I n d e x 14 Althea® (lotion) Intense moisturizer for dry skin Althea is a topical, phytopharmaceutical formulation recommended for the management of xerosis (abnormal skin dryness). Althea moisturizes the skin, restores skin hydration, replenishes critical skin lipids, supports the integrity of the natural skin barrier, and soothes dry, inflamed and itchy skin. Althea improves the appearance of the skin and promotes softer, healthier-looking skin. Althea is safe and dermatologically tested. Althea is non-sticky, non-staining, and free from mineral oil, parabens, fragrances and artificial colors. Composition Each gram of Althea cream contains: Each gram of Althea lotion contains: Exts. Exts. VrikshamLa (Garcinia indica)........................................5 mg VrikshamLa (Garcinia indica)...................................5 mg Shali (Oryza sativa)...........................................................1 mg Shali (Oryza sativa)......................................................1 mg Kumari (Aloe vera)............................................................1 mg Kumari (Aloe vera). ......................................................1 mg Oil Oil Narikela (Cocos nucifera)............................................. 10 mg Narikela (Cocos nucifera)........................................ 10 mg Clinical Pharmacology Althea has moisturizing, skin barrier-restoring, anti-inflammatory, immunomodulatory, and antimicrobial actions. The moisturizing action of Althea helps retain moisture and soften the dry, scaly skin in xerosis. The antiinflammatory and immunomodulatory properties of Althea overcome cutaneous inflammation and soothe the dry, sore and itchy skin, thus improving the quality of life. The antimicrobial properties of Althea inhibit the colonizing of microorganisms and prevent secondary bacterial infections of the compromised skin. Indications • Xerosis • Senile xerosis • As a moisturizer in the treatment of xerosis associated with: – Atopic dermatitis (eczema) – Ichthyosis – Psoriasis Directions for Use To be taken in liberal quantity and massaged gently on cleansed face and body, at least twice daily.
T h e r a p e u t i c I n d e x 15 Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Special Precautions • Should not be used by patients having hypersensitivity to any of the ingredients • Children under 12 years of age should use under adult supervision • To be used only for external application Presentation PET bottle of 100 mL. Pharmacological Actions of Ingredients 1. Moisturizing action: Polysaccharides in Aloe vera act as humectants by facilitating transfer of moisture to the skin, and thus improve the hydration of the stratum corneum layer of the skin. Medium and long-chain fatty acids (e.g., palmitic acid, stearic acid, linoleic acid, oleic acid, and lauric acid) in Garcinia indica butter and Cocos nucifera oil help exert an emollient effect by filling up the spaces between skin flakes, reduce transepidermal water loss (TEWL), and enhance epidermal barrier function, thus helping to maintain skin hydration and integrity. 2. Skin barrier restoration: The skin barrier function is determined by the integrity of the main constituents of stratum corneum—the corneocytes and intercellular lamellar lipid bilayers. The lipids that constitute the stratum corneum are ceramides, cholesterol, and free fatty acids, which are responsible for the water permeability and the exchange of substances with the external environment. The unique, naturally occurring ceramides in Oryza sativa bran help replenish the skin lipids, significantly increase water content in the stratum corneum, significantly reduce transepidermal water loss (TEWL), and restore effective skin barrier function. Oryza sativa ceramides induce the hyaluronan synthase gene expression and prevent the degradation of hyaluronic acid, a key molecule having a unique capacity to bind and retain molecules in the skin and improve skin hydration. The ceramides from Oryza sativa and polysaccharides from Aloe vera increase the concentration of filaggrin and involucrin, two key proteins that participate in building the corneocyte cytosol, the cornified envelope, and the links between corneocytes. Oryza sativa ceramides and Aloe vera polysaccharides also upregulate the gene expression of aquaporin-3, a water/glycerol-transporting protein in the skin, which plays an important role in skin hydration, elasticity and integrity. 3. Anti-inflammatory and immunomodulatory actions: Several cytokines contribute to efficient skin barrier formation by influencing the composition of the lipid envelope, cell–cell adhesion, and the cornification process. Deregulated cytokine expression in the skin can weaken barrier function and thus aggravate the inflammatory response. Althea® (lotion)
T h e r a p e u t i c I n d e x 16 The anti-inflammatory property of Aloe vera, Cocos nucifera and Oryza sativa, combined with the immunomodulatory effect of Aloe vera, helps modulate immune response in the skin and deters the cutaneous inflammatory response through inhibiting key proinflammatory cytokines (namely, tumor necrosis factor (TNF)-α, interleukin (IL)-5, IL-6, and interferon (IFN)-γ). 4. Antimicrobial action: Staphylococcus aureus and Candida albicans are among the most common microorganisms that colonize the atopic skin, endangering secondary infection facilitated by the compromised skin barrier. Ceramidase from the skin-colonizing Pseudomonas aeruginosa, activated by Staphylococcus aureus-derived glycerophospholipids, causes the hydrolysis of ceramides, leading to degradation of the barrier function in atopic skin. Aloe vera and Cocos nucifera oils exhibit inhibitory effect against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Althea® (lotion)
T h e r a p e u t i c I n d e x 17 Composition Each gram of Bleminor cream contains: Exts. Yashti (Glycyrrhiza glabra)..................................... 1.7 mg Sarja (Vateria indica)................................................ 0.8 mg Shalmali (Bombax malabaricum)........................ 0.1 mg AmLaparni (Rheum emodi)................................... 0.1 mg Oil Vatada* (Prunus amygdalus).................................. 10 mg *Also known as Badama. Clinical Pharmacology Bleminor inhibits melanin synthesis through tyrosinase-inhibitory action without causing cytotoxicity. Bleminor also has anti-inflammatory, skin-protective, and complexion-improving actions. The anti-inflammatory action of Bleminor helps in the prevention of hyperpigmentation due to recurrent inflammation. Bleminor soothes and nourishes the skin and improves general skin health. Bleminor does not cause photosensitivity. Indications • Hyperpigmentation of varied etiology (like sun and UV exposure and aging) • Melasma • Post-injury and post-inflammatory hyperpigmentation Directions for Use After cleansing the face and neck, apply a sufficient quantity of Bleminor over the affected areas at least twice daily. Avoid the area around the eyes, nostrils, mouth, and ears. Bleminor® (cream) Manage blemishes effectively Bleminor, a phytopharmaceutical formulation, is recommended for the topical management of blemishes or skin hyperpigmentation occurring due to various causes such as excessive sun exposure, inflammatory conditions like acne, and hormonal disturbances. Bleminor has good tolerability and is safe for long-term use.
T h e r a p e u t i c I n d e x 18 Adverse Effects No clinically significant adverse effects have been reported. Contraindications No known contraindications. Precautions • Application should be limited to an area no larger than the face and neck, or hands and arms. • To be used exclusively for external application. • Contact with eyes or open wounds to be avoided. Presentation SeamLess tube of 30 mL. Pharmacological Actions of Principal Ingredients 1. Melanin synthesis-inhibitory action: Glabridin in Glycyrrhiza glabra has an inhibitory effect on pigmentation by inhibiting melanocyte tyrosinase activity without causing cytotoxicity. Gallic acid in Bombax malabaricum and Rheum emodi has excellent tyrosinase-inhibitory and antioxidant activities, which inhibit melanin production. The phenols in Vateria indica and the oil in Prunus amygdalus are natural antioxidants that help in decreasing melanin synthesis. They have proven activity in inhibiting melanogenesis. 2. Anti-inflammatory action: The anti-inflammatory property of glycyrrhizin in Glycyrrhiza glabra helps in the management of hyperpigmentation due to recurrent inflammatory conditions such as acne. 3. Skin-protective and complexion-improving actions: Glycyrrhizin in Glycyrrhiza glabra significantly inhibits photoaging by reducing reactive oxygen species (ROS), nuclear factor kappa B (NF-kB), cytochrome c, and caspase-3 levels. It inhibits the hyaluronidase enzyme in ultraviolet B (UVB) irradiation-induced photoaging in human dermal fibroblasts. The oil of Prunus amygdalus smooths and rejuvenates the skin, and is effective in improving skin complexion and tone. Bleminor® (cream)
T h e r a p e u t i c I n d e x 19 Composition Each mL of Bonnisan drops contains: Dill (Anethum graveolens) oil 0.00162 mL plus 0.45 mg of each of the following significant extracts: Guduchi (Tinospora cordifolia) Haritaki (Terminalia chebula) Himsra (Capparis spinosa) Sukshmaila (Elettaria cardamomum) Pippali (Piper longum) Biranjasipha (Achillea millefolium) Amalaki (Emblica officinalis) Jhavuka (Tamarix gallica) Kasani (Cichorium intybus) Gokshura (Tribulus terrestris) Kasamarda (Cassia occidentalis) Punarnava (Boerhaavia diffusa) Processed in Kamala (Nelumbium speciosum), Nagaramusta (Cyperus scariosus), Amalaki (Emblica officinalis), Sugandhavacha (Kaempferia galanga), Parpata (Fumaria officinalis), Vidanga (Embelia ribes), Arjuna (Terminalia arjuna), Guduchi (Tinospora cordifolia), Mishreya (Foeniculum vulgare), Yavanika (Ptychotis ajowan), Ushira (Vetiveria zizanioides), and Yashti (Glycyrrhiza glabra). Each 5 mL of Bonnisan liquid contains: Dill (Anethum graveolens) oil 0.0018 mL plus 0.5 mg of each of the following significant extracts: Guduchi (Tinospora cordifolia) Haritaki (Terminalia chebula) Himsra (Capparis spinosa) Sukshmaila (Elettaria cardamomum) Pippali (Piper longum) Biranjasipha (Achillea millefolium) Amalaki (Emblica officinalis) Jhavuka (Tamarix gallica) Kasani (Cichorium intybus) Gokshura (Tribulus terrestris) Kasamarda (Cassia occidentalis) Punarnava (Boerhaavia diffusa) Processed in Kamala (Nelumbium speciosum), Nagaramusta (Cyperus scariosus), Amalaki (Emblica officinalis), Sugandhavacha (Kaempferia galanga), Parpata (Fumaria officinalis), Vidanga (Embelia ribes), Arjuna (Terminalia arjuna), Guduchi (Tinospora cordifolia), Mishreya (Foeniculum vulgare), Yavanika (Ptychotis ajowan), Ushira (Vetiveria zizanioides), and Yashti (Glycyrrhiza glabra). Bonnisan® (drops, liquid) Keeps babies healthy and happy Bonnisan, a phytopharmaceutical formulation, is recommended for the prevention and treatment of common gastrointestinal (GI) disorders in infants and children. Bonnisan prevents the common digestive complaints as it stimulates digestive enzymes and helps expel trapped gases through its carminative action. Bonnisan helps restore the normal physiological functions of the digestive tract, enhances digestion, improves assimilation of nutrients, and ensures adequate weight gain.
T h e r a p e u t i c I n d e x 20 Clinical Pharmacology Bonnisan has carminative, antispasmodic, appetite-stimulating, anti-nauseating, mucoprotective and antisecretory, antioxidant, antimicrobial, anti-inflammatory, stomachic, hepatic-stimulant, hepatoprotective, mild laxative, and prebiotic actions. Bonnisan relieves the smooth muscle spasm associated with colic, protects the GI mucosa, removes entrapped gases from the GI tract, and offers protection against acute and chronic infections. Bonnisan helps infants and children gain weight adequately. Bonnisan helps restore the normal physiological functions of the digestive tract and ensures health and well-being. Indications • For the treatment of common digestive complaints in infants and children • As a daily health supplement in infants and children: – To prevent common digestive complaints – To promote healthy growth Dosage Drops: Infants up to 1 month: 5 to 10 drops (0.17 to 0.34 mL) thrice daily. 1 month to 6 months: 10 to 20 drops (0.34 to 0.68 mL) thrice daily. Liquid: Infants up to 1 month: ½ teaspoon (2.5 mL) thrice daily. 1 month to 6 months: 1 teaspoonful (5 mL) thrice daily. 6 months to 3 years: 2 teaspoonsful (10 mL) thrice daily. Adverse Effects No adverse effects have been reported. Contraindications No known contraindications. Drug Interactions No clinically significant drug interactions have been reported. Presentation Drops: Pilfer-proof bottle of 30 mL. Liquid: Pilfer-proof bottles of 100 mL and 200 mL. Pharmacological Actions of Principal Ingredients 1. Carminative action: Anethum graveolens, Piper longum, Cichorium intybus, Terminalia chebula, Elettaria cardamomum, and Kaempferia galanga have potent carminative actions that help relieve flatulence and prevent gaseous distension. Anethum graveolens is a well-known remedy for flatulence in children. 2. Antispasmodic action: Tinospora cordifolia, Capparis spinosa, Piper longum, Emblica officinalis, Cichorium intybus, Terminalia chebula, Elettaria cardamomum, Achillea millefolium, Boerhaavia diffusa, Fumaria officinalis, Embelia ribes, Foeniculum Bonnisan® (drops, liquid)
T h e r a p e u t i c I n d e x 21 Bonnisan® (drops, liquid) vulgare, and Glycyrrhiza glabra have potent antispasmodic and pain-relieving actions, which along with their carminative action, help relieve symptoms of colic in GI disorders in infants and children. 3. Appetite-stimulating action: Elettaria cardamomum is used to renormalize digestion and stimulate appetite. 4. Anti-nauseating action: Cichorium intybus is used for checking bilious vomiting. Elettaria cardamomum is used as an antidote to nausea. 5. Mucoprotective and antisecretory actions: Anethum graveolens, Emblica officinalis, and Glycyrrhiza glabra have potent mucoprotective and antisecretory actions. The extract of Elettaria cardamomum causes a significant decrease in gastric acid secretion after treatment. 6. Antioxidant action: Functional GI diseases such as non-ulcer dyspepsia (NUD), in many cases, are initiated by or correlated with inflammatory processes where reactive oxygen species (ROS) play a crucial role. Prominent sources of ROS are myeloperoxidase (MPO)-driven oxidation and chlorination reactions, which are assumed to be mainly responsible for tissue damage. Anethum graveolens, Tinospora cordifolia, Capparis spinosa, Emblica officinalis, Cichorium intybus, Terminalia chebula, Achillea millefolium, Boerhaavia diffusa, Nelumbium speciosum, Foeniculum vulgare, and Glycyrrhiza glabra have potent antioxidant properties that offer protection against oxidative damage. Tamarix gallica has potent chemopreventive properties that may suppress hepatic oxidative stress. 7. Antimicrobial action: NUD is commonly seen in children. Various microbial pathogens are associated with GI disorders, leading to indigestion, NUD, and diarrhea. Escherichia is one of the most common microorganisms associated with diarrhea. Anethum graveolens, Capparis spinosa, Cassia occidentalis, and Terminalia chebula have broad-spectrum antimicrobial action, useful in the prevention and treatment of acute and chronic GI infections. 8. Anti-inflammatory action: Bonnisan also has potent anti-inflammatory action that controls the damage associated with acute and chronic GI infections. Tinospora cordifolia, Capparis spinosa, Piper longum, Emblica officinalis, Cichorium intybus, Cassia occidentalis, Terminalia chebula, Elettaria cardamomum, Achillea millefolium, Tribulus terrestris, Cyperus scariosus, Embelia ribes, Terminalia arjuna, Foeniculum vulgare, and Glycyrrhiza glabra have potent anti-inflammatory action that controls the damage associated with acute and chronic GI infections. 9. Stomachic action: Anethum graveolens, Terminalia chebula, and Tribulus terrestris have stomachic property.
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