Probe • Vol LXII • No. 4 • Sep–Dec 2023 • 31 Urology Urinary Tract Infection in Patients With Diabetes Mellitus and the Role of Parental Genetics in the Emergence of the Disease This study assessed the role of parental genetics in the development of diabetic mellitus (DM) and determine the effect of DM on the urinary system. The study included 100 people with DM (age, 5–83 y). Blood sugar levels were evaluated clinically. Information about the age, gender, causes of DM, and the family history of diabetes was reported. Isolation and identification of bacterial species were made depending on culture media and biochemical tests. The average age of patients was 47.7 ± 5.5 years, and most of them were female. The incidence of DM increased with age, and the main cause of DM was likely to be a genetic predisposition, where 32% of the patients appeared to have a positive family history and the presence of DM in both parents, or only the mother had a significant role in increasing the genetic predisposition of developing DM. Among the nongenetic causes, the most common was exposure to sudden psychologic or nervous shock. Obesity, pregnancy, and smoking also play an important role in the development of DM. Moreover, 66% of the patients with type 2 DM and all with type 1 DM suffered from UTIs. The main causative agents of UTIs were Escherichia coli and Proteus spp. Around 73% of the patients suffering from UTIs were females. Type 2 DM is the most common, especially in females, and its incidence increases with age. The main cause of DM was family genetic predisposition and sudden shocks. Source: Al Qurabiy HE, et al. J Med Life. 2022;15(8):955–962. Diabetes Mellitus as a Predictive Factor of Urinary Tract Infection in Patients TreatedWith Kidney Transplantation This study investigated the rate of incidence and risk factors of posttransplant urinary tract infection (UTI) in patients who received kidney transplantation (KT). This retrospective cohort study was carried out in patients who underwent KT for end-stage kidney disease (ESKD), between January 2008 and December 2021, at Gifu University Hospital (Gifu, Japan). UTI was defined as the existence of bacterial and/or fungal infection in urine with ≥ 105 CFU/mL, with or without urinary and/or systemic symptoms of UTI. Patients were divided into 2 groups: those with UTI after KT (UTI group) and those without UTI (non-UTI group). The primary end point of this study was the relationship between covariates and UTI after KT. Two hundred and forty patients with ESKD received KT at Gifu University Hospital. Thirty-four patients developed UTI after surgery, and the most common pathogen was Escherichia coli. At the end of the follow-up, graft loss was observed in 6 patients (2.5%), independent of UTI episodes. In multivariate analysis, diabetes mellitus (DM) was statistically associated with posttransplant UTIs in KT recipients. Thus, to conclude, preoperative serum glucose control in patients with DM may have a crucial role in preventing UTIs and preserving renal functions after KT. Source: Ozawa K, et al. Medicina (Kaunas). 2022;58(10):1488. Abstracts From Literature
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