8 • Probe •Vol LXII • No. 4 • Sep–Dec 2023 Clinical Evidence 1 Pilex® (TABLET) Pilex Tablet is an Ayurvedic proprietary formulation recommended for the comprehensive management of hemorrhoids. Pilex Tablet has anti-inflammatory, analgesic, wound-healing, antimicrobial, hemostatic, laxative, and antioxidant actions. The ingredients of Pilex Tablet act synergistically to bring about a reduction in the hemorrhoidal mass and facilitate early resolution of symptoms such as rectal bleeding, pain, and itching, and correct chronic constipation associated with hemorrhoids. Efficacy of Pilex® in the Treatment and Management of External and Internal Hemorrhoids Aim To evaluate the efficacy and safety of Pilex Tablets in the treatment and management of mild-to-moderate external and internal hemorrhoids Materials and Methods This open-label, clinical study enrolled 50 patients (aged 22–63 y; both men and women), of whom 31 patients had external hemorrhoids, 10 patients had internal hemorrhoids, and 9 patients had both internal and external hemorrhoids. All patients received 1 Pilex Tablet, BID, for 6 weeks. Concomitant treatment with other hemorrhoidal drugs was discontinued during the study period. Proctoscopic examination was done before treatment and at every fortnightly follow-up during the treatment period. During the follow-ups, the patients were evaluated for the reduction in the size of the hemorrhoidal mass, pain during defecation, bleeding during defecation, anal pruritus, strenuous bowel movements, and loss of appetite. The intensity of the signs and symptoms was graded on a 4-point scale as 0, absent; 1, mild; 2, moderate; and 3, severe. At the end of the study, the efficacy of the treatment was recorded as either very good, good, or not effective. Results Thirty-two patients completed the treatment, while the remaining patients were lost to follow-up. Treatment with Pilex Tablets showed a significant reduction in the symptoms of hemorrhoids such as pain and bleeding and a significant improvement in the general health of the patients. The treatment response was recorded as very good in 56.25% of the patients and good in 37.50% of the patients. No side effects were observed during the study. Conclusion The results confirmed that Pilex Tablets are safe and effective in the treatment and management of mild-to-moderate internal and external hemorrhoids. The astringent, antiseptic, anti-inflammatory, and demulcent properties of Pilex Tablets helped reduce the pain and inflammation of hemorrhoids. The laxative property of Pilex Tablets helped relieve constipation associated with hemorrhoids. The antibacterial and astringent properties of Pilex Tablets helped prevent infection and healed the ulcers. Pilex Tablets also helped in shrinking the hemorrhoidal mass. Summary • This open-label clinical study enrolled 50 patients; 31 patients had external hemorrhoids, 10 patients
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