Probe • Vol LXII • No. 4 • Sep–Dec 2023 • 7 Effect of Diabecon in the Management of Diabetic Retinopathy Syzygium cuminii, Tinospora cordifolia, and Ocimum sanctum have aldose reductase–inhibitory actions, and thus, prevent the acceleration of cataract formation in diabetics. Conclusion Diabecon is a safe and effective adjuvant in the management of retinopathy in diabetic patients. Summary • Thirty patients with non–insulin-dependent diabetes mellitus (NIDDM) and insulindependent diabetes mellitus (IDDM) were included in this study, and the patients were graded according to the classification of diabetic retinopathy. • All patients received Diabecon at a dosage of 2 tablets, TID, for 12 weeks, in addition to conventional antidiabetic treatment; they were followed up at intervals of 1 month, for 3 months. • Diabecon caused inhibition of microaneurysm, resolved retinal and vitreous hemorrhage, inhibited the proliferative changes in the retina and controlled progressive retinal damage, improved vision, and caused a considerable improvement in neovascularization and resolution of exudates. • The results suggest that Diabecon is a safe and effective adjuvant in the management of retinopathy in diabetic patients. Sources: Anturlikar SD, et al. Indian J Physiol Pharmacol. 1995;2(39):95–100. Kohli KR, et al. Antiseptic. 2004;101(11):487–494. Kant S, et al. Indian J Clin Pract. 2002;12(9):49–56. Figure 3. Effect of Diabecon on Exudates in Diabetic Retinopathy Figure 4. Effect of Diabecon on Retinitis Proliferans in Diabetic Retinopathy 2.50 1.00 0.50 1.50 2.00 2.03 ± 0.81 1.31 ± 0.81 0 Mean Value Before Treatment After Treatment 0.60 0.30 0.20 0.10 0.40 0.50 0.55 ± 0.89 0 Mean Value Before Treatment After Treatment 0.58 ± 0.92 examination revealed a considerable improvement in neovascularization and resolution of exudates. During the course of the study and after the withdrawal of Diabecon, no adverse effects were reported. Discussion Diabecon acts as an effective adjuvant to conventional oral hypoglycemic agents where the resolution of retinopathy is enhanced. Diabecon resolves, prevents, and retards retinal and vitreal microaneurysms and proliferative retinal changes. Curcuma longa, with its antioxidant and antiangiogenic actions, inhibits Ca2+ entry and protein kinase C activity, which helps prevent diabetic retinopathy. Gymnema sylvestre, Pterocarpus marsupium,
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