6 • Probe •Vol LXII • No. 4 • Sep–Dec 2023 Clinical Evidence 2 Effect of Diabecon® in the Management of Diabetic Retinopathy Aim To evaluate the effect of Diabecon in the management of diabetic retinopathy Materials and Methods This study included 30 patients with either non– insulin-dependent diabetes mellitus (NIDDM) or insulin-dependent diabetes mellitus (IDDM). Patients were graded according to the classification of diabetic retinopathy. They were monitored using modern diagnostic investigations such as direct/ indirect ophthalmoscopy, fluorescein angiography, and fundus photography. The patients were graded according to the Airlie House Classification and eye testing for diabetic retinopathy. All patients received Diabecon at a dosage of 2 tablets, TID, for 12 weeks, in addition to conventional antidiabetic treatment, and were followed up at intervals of 1 month, for 3 months. The mean symptom grades during each visit were noted and compared with the baseline symptom scores. Results The findings of this study suggest that there was a significant inhibition of microaneurysm; the mean grade in microaneurysm was 2.228 ± 4.084 before treatment and 0.466 ± 0.650 after 90 days of treatment with Diabecon (Figure 1). The mean grade of hemorrhage was 2.034 ± 0.815 before treatment and reduced to 0.866 ± 0.832 after treatment, thus, suggesting that Diabecon helps in resolving retinal and vitreous hemorrhage (Figure 2). The mean grade of exudates reduced from 2.034 ± 0.816 before treatment to 1.316 ± 0.81 after treatment (Figure 3). This significant reduction in exudation demonstrates the anti-inflammatory effect of Diabecon. The overall mean grade of retinitis proliferans reduced from 0.583 ± 0.925 before treatment to 0.550 ± 0.891 after treatment (Figure 4). Diabecon inhibited the proliferative changes in the retina and controlled progressive retina damage. The visual acuity of each patient was measured before and after administering Diabecon. On the Snellen chart, it was observed that 60% of the patients showed improvement in vision by at least one line. Funduscopic Figure 1. Effect of Diabecon on Microaneurysm in Diabetic Retinopathy 2.50 1.00 0.50 1.50 2.00 2.22 ± 4.08 0.46 ± 0.65 0 Mean Value Before Treatment After Treatment Figure 2. Effect of Diabecon on Hemorrhage in Diabetic Retinopathy 2.50 1.00 0.50 1.50 2.00 2.03 ± 0.81 0 Mean Value Before Treatment After Treatment 0.86 ± 0.83
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