32 • Probe •Vol LXII • No. 3 • May–Aug 2023 Abstracts From Literature Cardiology Blood Pressure Measures and Incident Primary Open-Angle Glaucoma This study investigated the association of systemic blood pressure with incident primary open-angle glaucoma (POAG) using a large, open access database. This prospective cohort study included 484,268 participants from the UK Biobank who did not have glaucoma at enrollment. Incident POAG events were recorded through assessment visits, hospital inpatient admissions, and primary care data. Blood pressure measures included systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP). Repeated measurements throughout the study period were analyzed as time-varying covariables. The parameters were modeled as both categorical and continuous nonlinear variables. The primary outcome measure was the relative risk of incident POAG. There were 2390 incident POAGs over 5,715,480 person-years of follow-up. The median follow-up was 12.08 years. In the multivariate analyses, higher SBP and PP (normal range: SBP, 120–130 mmHg; PP, 40–50 mmHg) were associated with an increased risk of incident POAG. Specifically, an SBP of 130 to 140 or 140 to 150 mmHg was associated with a 1.16 higher risk of incident POAG (95% CI: 1.01–1.32 and 1.01–1.33, respectively), whereas a PP > 70 mmHg was associated with a 1.13 higher risk of incident glaucoma (95% CI: 1.00–1.29). In multivariate models, no statistically significant associations were found for DBP or MAP with incident glaucoma. These findings were similar when blood pressure measures were modeled as continuous variables. It is seen that higher SBP and PP were associated with an increased risk of incident POAG. Source: Macri C, et al. Invest Ophthalmol Vis Sci. 2022;63(13):3. Effect of fQRS on the Occurrence of Ventricular Fibrillation in Patients With Variant Angina This study evaluated the effect of fragmented QRS (fQRS) on the occurrence of ventricular fibrillation (VF) in patients with variant angina (VA). Ninety-four patients who showed ST elevation on 12-lead ECGs with total or nearly total occlusion in response to the coronary spasm provocation test were enrolled. Among them, 16 patients had documented VF before hospital admission (n = 12) or experienced VF during the provocation test (n = 4) (VF occurrence group). The fQRS was defined as the presence of spikes within the QRS complex of 2 or more consecutive leads. The prevalence of fQRS was more often observed in the VF occurrence group than in the non–VF occurrence group (63% [10 of 16] vs 27% [21 of 78], P = .009). Univariate analyses revealed that age, history of syncope, QTc, and the presence of fQRS were associated with VF occurrence (P = .004, .005, .029, and .008, respectively). Furthermore, upon multivariate analyses using those risk factors, age, QTc, and fQRS predicted VF occurrence independently (P = .007, .041, and .014, respectively). This study demonstrated that fQRS in patients with VA is a risk factor for VF. The fQRS may be a useful factor for the risk stratification of VF occurrence in patients with VA. Source: Shinohara T, et al. Ann Noninvasive Electrocardiol. 2022;27(3):e12937.
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