30 • Probe •Vol LXII • No. 3 • May–Aug 2023 DRUG ALERT Assessment of Adverse Drug Reactions of Antidepressant Drugs Used in the Psychiatry Department of a Tertiary Care Hospital The aim of the study was to analyze the adverse drug reactions (ADRs) reported in patients prescribed antidepressant drugs at a tertiary care hospital. A prospective, observational study was conducted from January 2020 to July 2021 at the Department of Pharmacology in collaboration with the Department of Psychiatry of GSVM Medical College (Kanpur, Uttar Pradesh, India). All patients diagnosed with depression and receiving pharmacotherapy were included in the study. ADRs were monitored using the standard form of the Central Drugs Standard Control Organization, and causality was determined using the Naranjo scale. Data were evaluated for patients’ demography, risk factors for ADRs, and the pattern of the ADRs. A total of 293 ADRs were recorded in 110 patients. The most common ADRs observed were anxiety (47.42%) and insomnia (19.22%). Men (58.18%) were most commonly affected than women (41.82%). Escitalopram (27.27%) and venlafaxine (21.81%) were the drugs that caused most ADRs. The most common systems involved were the central nervous system (53.24%) followed by the gastrointestinal system (41.63%). Most ADRs (97.95%) were possible according to the Naranjo scale. Anxiety, insomnia, and dizziness were the common ADRs that were associated with the use of antidepressants. This study offers a representative profile of the ADRs that can be expected in psychiatry outpatients. Source: Kushwaha V, et al. Asian J Pharm Clin Res. 2022;15(4):49–54. Adverse Drug Reaction Profile of Daily Regimen Antituberculosis Treatment The aim of the study was to estimate the proportion of adverse drug reactions (ADRs) to daily regimen antituberculosis treatment (ATT) among the ADRs documented in the ADR monitoring center (AMC) of the institution and to describe their pattern. This descriptive study was conducted in the Department of Pharmacology of the Government Medical College (Kottayam, Kerala, India), from October 2017 to June 2020. The data about ADRs were entered into a structured pro forma and analyzed using SPSS for Windows, version 16.0 (SPSS Inc, Chicago, IL, USA). Of the 643 ADRs, 98 (15.24%) were suspected to be due to the daily regimen of ATT. The most common organ systems affected were the hepatobiliary system (46.9%; hepatitis in 35 patients and asymptomatic elevated liver enzymes in 11 patients) followed by the eyes (26.5%; 26 patients with a decreased vision). In 96 (97.95%) patients, the suspected ADRs had a probable causality, and in 2 (2.04%) patients, it was a possible causality. Seventy-seven (78.6%) ADRs were serious and moderate level 4b in severity, and 57 (58.16%) ADRs were probably preventable. The mean days of onset of an ADR after starting the ATT regimen were 56.40 ± 58.29 (range 1–180) days. A decrease in vision with a mean duration of 125.23 ± 55.46 days had the longest latency in the onset among all the ADRs. Of all the ADRs reported to AMC, 15.24% were due to the daily regimen of ATT. Source: Sankar KNH, et al. Perspect Clin Res. 2022;13(4):194–198.
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