12 • Probe •Vol LXII • No. 3 • May–Aug 2023 dose was increased to 1 teaspoon, TID, for infants and 2 teaspoons, TID, for children. The treatment was administered for 12 to 16 weeks. • After the treatment with Septilin syrup, 50% of the patients showed an excellent response and remaining 50% showed good response. • After prescribing Septilin syrup, the avoidance of antibiotics was possible in 75% of cases, and the remaining 25% were given antibiotics. • No side effects were observed in patients treated with Septilin syrup. • At follow-up, majority of the patients reported improved symptoms, and all patients reported good appetite and weight gain. Sources: Rao CS, et al. Indian J Exp Bio. 1994;32:553–558. Rajarathna K, et al. Med Update. 2010;18(8):23–27. Gaunekar L, et al. Antiseptic. 1988;4:250–251. Effect of Septilin on S aureus–induced sepsis S aureus was administered intravenously for 24 hours. There was a 66.6% mortality in the control group (n = 15), while 20% mortality (n = 12) in the Septilin-treated group. After 48, 72, 96, and 120 hours, no more mortality was noted. Effect of Septilin on carbon clearance The total area under the time–absorbency curve in the Septilin-treated group was 10.06 ± 0.71 and 15.46 ± 1.78 in the control group. Effect of Septilin on humoral response in normal and immunedeficient rats Septilin increased the titer of anti-SRBC hemagglutination antibodies in normal rats by 5.7 fold and showed remarkable resistance to cyclophosphamide-induced humoral suppression. This suggests a significant potentiating action of Septilin on humoral immunity. Conclusion The results of the study suggest that Septilin treatment increased the number of neutrophils in mice, increased the bactericidal activity of neutrophils in rats, accelerated the elimination of colloidal carbon, and prevented mortality from E coli–induced abdominal sepsis in mice. Septilin treatment reduced bacteremia after injecting S aureus in neutropenic mice, potentiated humoral immunity in rats, and counteracted cyclophosphamide-induced humoral suppression in rats. Summary • This study included Swiss albino mice and wistar rats for different study methods, and they were treated with Septilin syrup at a dosage of 20 mL/kg body weight, once daily, orally for 15 days. • Septilin-treated rats showed a 5.7-fold rise in anti-SRBC hemagglutination antibody titer mediated by IgG and IgM. • Septilin showed a potentiating effect on humoral immunity. ...Continued from page 8 (Immunotherapeutic Modification by Septilin) Effect of Septilin Syrup on Recurrent Upper Respiratory Tract Infections in Children
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