10 • Probe •Vol LXII • No. 3 • May–Aug 2023 with continued treatment (Table 2). In URTIs, of the 28 patients with tonsillitis, only 17, 8, and 3 patients had tonsillitis by the end of the second, fourth, and sixth weeks, respectively. Among the 24 patients with pharyngitis, only 8 and 2 patients had pharyngitis by the end of the second and fourth weeks; and by the end of 6 weeks, none of the patients had the condition. Patients with sinusitis were advised steam inhalation along with Septilin therapy. Of the 20 patients with sinusitis, only 12, 7, and 2 patients had sinusitis by the end of the second, fourth, and sixth weeks, respectively. Patients with rhinitis (n = 31) were also advised steam inhalation along with Septilin therapy. The symptoms reduced significantly by 2 weeks, and all the patients responded well by 4 weeks. In patients with LRTIs, 36 of them presented with bronchitis; of which only 20, 11, and 4 had the symptoms by the end of the second, fourth, and sixth weeks, respectively. Of the 148 patients treated, only 2 patients experienced mild abdominal discomfort, and all the patients tolerated the drug well. None of the patients were withdrawn from the study due to adverse effects. Discussion Septilin is a polyherbal preparation, and the effect of the formulation is due to the synergistic action of the ingredients. The principal herbs present in Septilin include Tinospora cordifolia, Emblica officinalis, Glycyrrhiza glabra, Moringa pterygosperma, Balsamodendron mukul, and Rubia cordifolia. T cordifolia has potent immunomodulatory and immunostimulatory properties, which increase the levels of antibodies and activate macrophages. It also improves phagocytic and intracellular bactericidal capacities of neutrophils. E officinalis enhances cell survival and increases phagocytosis and IFN-γ production. Glycyrrhizin from G glabra potentiates the reticuloendothelial system, enhances immunostimulation, and acts on macrophage function in vitro, leading to stimulation of macrophages de novo. β-Glycyrrhetinic acid from G glabra is a potent inhibitor of the classical complement pathway. E officinalis has antibacterial property, especially against Escherichia coli, Klebsiella pneumoniae, Klebsiella ozaenae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Salmonella paratyphi A and B, and Serratia marcescens. B mukul has strong anti-inflammatory potential. R cordifolia has antibacterial property. M pterygosperma possesses antibacterial and antiviral properties and inhibits the growth of gram- positive and gram-negative bacteria such as E coli, S typhi, and S paratyphi. T cordifolia and E officinalis possess antipyretic property. Conclusion The study revealed that Septilin tablets significantly alleviated the symptoms of URTIs and LRTIs, and Septilin was safe and well tolerated in patients at the dose administered. Summary • This study included 148 patients with URTIs and LRTIs. • All patients were prescribed Septilin tablet at a dosage of 2 tablets, BID, for 6 weeks. • The symptoms were reduced, and gradual improvement in response to the treatment was noticed after 2 weeks. Further improvement was observed with continued treatment. • No adverse effects were observed in patients treated with Septilin. Efficacy and Safety of Septilin Tablet in the Management of Respiratory Tract Infections
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