18 • PERINATOLOGY Vol 24 • No. 1 • May–Aug 2023 Table 5. Correlation Between Cord Blood Lactate Level and Immediate Cry at Birth Activity of the Neonates Cord Blood Lactate Level, mmol/L, Median (IQR) P Value Cried at Birth Yes 2.90 (2.11–3.60) 0a No 6.26 (6.11–10.34) aP < .001, highly significant. Table 6. Correlation Between the Severity of PIH in the Mothers and Cord Blood Lactate Level PIH Total, n Cord Blood Lactate Level, mmol/L, Median (IQR) P Value Gestational Hypertension 34 2 (1.8–3.3) .012a Preeclampsia 41 4 (2.4–5.8) Eclampsia 4 2 (1.1–3.1) aP < .05, significant. PIH, pregnancy-induced hypertension. The correlation between cord blood lactate level and the method of oxygen inhalation in the neonates was highly significant (P = 0) (Table 7). • Group with cord blood lactate level < 3 mmol/L versus group with lactate level 3 to 8 mmol/L: P = .002 Table 7. Distribution of Neonates Based on Cord Blood Lactate Level and the Method of Oxygen Inhalation Method of Oxygen Inhalation No. of Neonates, n Cord Blood Lactate Level, mmol/L, Median (IQR) Cord Blood Lactate Level P Value < 3 mmol/L, n (%) 3–8 mmol/L, n (%) > 8 mmol/L, n (%) Room Air 38 2.3 (1.8–3.0) 27 (71) 11 (31) 0 0a Oxygen via Nasal Prongs 14 3.2 (2.7–5.5) 6 (16) 8 (22) 0 CPAP 13 3.3 (2.4–5.2) 4 (10) 9 (25) 0 Ventilator 14 6.4 (5.0–9.5) 1 (3) 8 (22) 5 (100) Total — — 38 (100) 36 (100) 5 (100) aP < .001, highly significant. CPAP, continuous positive airway pressure. Table 8. Correlation Between Cord Blood Lactate Level and Neonatal Mortality Neonatal Outcome Cord Blood Lactate Level, mmol/L, Median (IQR) P Value Alive 3 (2.0–3.5) 0a Dead 8 (5.8–10.2) aP < .001, highly significant. Table 9. Correlation Between Cord Blood Lactate Level and Neonatal Outcome Cord Blood Lactate Level, mmol/L Total Number of Neonates, n Alive, n (%) Dead, n (%) P Value < 3 38 38 (100) 0 0a 3–8 36 30 (83) 6 (17) > 8 5 0 5 (100) Total 79 68 11 aP < .001, highly significant. • Group with cord blood lactate level 3 to 8 mmol/L versus group with lactate level > 8 mmol/L: P = .000 • Group with cord blood lactate level < 3 mmol/L versus group with lactate level > 8 mmol/L: P = .031 Tables 8 and 9 present the correlation between cord blood lactate level and neonatal mortality; the correlation was found to be highly significant (P = 0). Research Article Kumar N, et al. Cord Blood Lactate Level and Neonatal Mortality in PIH Discussion Of the 79 neonates born to women with PIH, 38 (48%) neonates were managed on room air, 14 (18%) neonates on oxygen via nasal prongs, 13 (16%) neonates on CPAP, and 14 (18%) neonates required ventilator. Totally, 32% of preterm neonates needed ventilator. Most of the term neonates (72%) were managed on room air. The maturity of the neonates at birth significantly affected the requirement of oxygenation (P = 0). All the neonates kept on room air or oxygen via prongs were alive. Of the 14 neonates who needed ventilator, 10 (71%) died. The outcome of neonates with severe respiratory distress who were on ventilator was poor (P = 0). No comparative data were available to corroborate the findings of this study.
RkJQdWJsaXNoZXIy MjAwNDg=