16 | Himalaya Livline | Vol 6 | No. 5 | Sep–Dec 2023 Liver Health Associations journal Facts Therapeutic Advances in Gastroenterology Image source: https://www.google.com/ search?rlz=1C1GCEU_enIN1020IN1020&q=therapeut ic+advances+in+gastroenterology&tbm=isch&sa=X &ved=2ahUKEwiV0ZuGi8X_AhXEVWwGHTr9AAcQ0pQ JegQIDhAB&biw=1366&bih=625&dpr=1 Diabetes Mellitus • The 4 metabolic abnormalities observed in diabetic patients are obesity, increased endogenous glucose output, abnormal insulin action, and insulin secretion dysfunction.1 • More than 90% of patients with diabetes have type 2 diabetes mellitus.1 • Diabetic patients are at an increased risk of tuberculosis, severe gram-positive infections, hospital-acquired postoperative infections, urinary tract infections, and tropical diseases.2 • Diabetic patients are 1.5 times more likely to experience cognitive dysfunction and dementia.3 • Disruption of intestinal flora can cause diabetes as intestinal permeability, inflammation, the immune system, and energy metabolism are affected.4 • Overnutrition affects diversity and stability of the intestinal flora and increases pathogenic microflora, causing low-grade inflammation in the gut that could lead to insulin resistance and diabetes mellitus.4 References 1. Guo H, et al. Int J Mol Sci. 2023;24(8):6978. 2. Harding JL, et al. Diabetologia. 2019;62(1): 3–16. 3. Varghese SM, et al. Front Public Health. 2022;10:822062. 4. Aydin OC, et al. World J Clin Cases. 2023;11(1):65–72. Therapeutic Advances in Gastroenterology is a peer-reviewed, open access journal launched in 2008. The journal publishes original articles, reviews, and scholarly comments on research and innovative studies pertaining to all areas of gastrointestinal and hepatic disorders. The journal exclusively publishes clinical research studies. It caters to an international audience of clinicians and researchers in gastroenterology and related disciplines, thus, providing an online platform for disseminating recent research and findings in the field. International Society of Liver Surgeons The International Society of Liver Surgeons (ISLS) was founded in 2016 to foster both academic and educational developments in the surgical treatment of liver and biliary diseases. The ISLS aims to disseminate scientific advances in hepatopancreato-biliary (HPB) surgery; liver transplantation; and laparoscopic, robotic, and endoscopic treatments of liver diseases. Its mission is to bring together surgical and medical experts from around the globe who treat patients with hepatobiliary and pancreatic diseases to improve the understanding of these diseases and enhance research capacity. The ISLS also comprises the ISLS Study Groups Platform, a unique platform that aims at increasing the survival rate and improving the quality of life of people suffering from liver diseases by creating awareness about the latest developments in liver transplantation and HPB surgery. https://www.isls-liversurgeon.org/
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