8 | Himalaya Livline | Vol 6 | No. 5 | Sep–Dec 2023 500 mg/kg, respectively, along with CCl4, for 4 days. The results revealed that the rats treated with E alba extracts showed a significant decrease in the serum ALT, AST, ALP, and total bilirubin levels, demonstrating an effective hepatoprotective property. Histopathology of the liver showed that groups 4 and 5 exhibited high degree of protection of the liver against CCl4-induced hepatotoxicity. The outcome was comparable to that of silymarin.2 References 1. Jahan R, et al. Int Sch Res Notices. 2014;2014:385969. 2. Beedimani RS, Shetkar S. Int J Basic Clin Pharmacol. 2015;4(3):404–409. P amarus extract at doses of 100, 200, and 300 mg/kg (dissolved in 0.2 mL distilled water), respectively, for 30 days. The results showed that oral administration of P amarus extract to mice with CCl4-induced liver damage significantly mitigated the toxic effects of CCl4 in a dose-dependent manner. The findings suggest that P amarus extract has potent hepatoprotective activity.3 References 1. Dossou-Yovo HO, et al. Sci World J. 2021;2021:6650704. 2. Sidhu MC, Singh R. Plant Arch. 2020;20(2): 4901–4906. 3. Krithika R, Verma RJ. Acta Pol Pharm. 2009;66(4):439–445. herb facts Eclipta alba Eclipta alba is an annual herb that grows up to 30 to 40 cm tall. The stem is cylindrical or flat and red; the leaves are oblong, sessile to subsessile, and about 2 to 6 cm long; and the seeds are dark brown. The herb possesses anticancer, hepatoprotective, anti-inflammatory, and antimicrobial properties.1 A study evaluated the hepatoprotective activity of aqueous extract of E alba against carbon tetrachloride (CCl4)– induced hepatotoxicity in male albino rats. Thirty rats were divided into 5 groups (6 rats each): group 1 received 1 mL/kg of vehicle; group 2 (toxic control) was administered CCl4 (2 mL/kg) intraperitoneally; group 3 received silymarin (50 mg/kg) along with CCl4; and groups 4 and 5 received the aqueous extract of E alba at doses 250 and Phyllanthus amarus Sanskrit name: Bhumyamalaki English name: Stone Breaker Phyllanthus amarus is an annual, glabrous, erect herb that grows up to 60 to 75 cm tall. The stem is branched at the base and angular with numerous leaves; the roots are stout and woody; the seeds are trigonous and brownish black; and the fruit is a capsule and appears green.1,2 A study evaluated the hepatoprotective effect of P amarus plant extract against CCl4-induced liver damage in female mice models. Inbred female Swiss albino mice aged 6 to 8 weeks were considered for the study. Seventy mice were divided into 7 groups (10 mice each): group 1 served as untreated control; group 2 received CCl4 (dissolved in 0.2 mL olive oil); group 3 served as plant control and received P amarus extract (300 mg/kg) in 0.2 mL distilled water; group 4 received a high dose of CCl4 (826 mg/kg dissolved in 0.2 mL olive oil); and groups 5, 6, and 7 received a high dose of CCl4 along with Sanskrit name: Bhringaraja English name: False Daisy
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