Evecare • Vol 11 • No. 2 • Sep–Dec 2023 16 In the World of Medicine A recent study published in BMC Medicine examined the association between Energy-adjusted Diet Inf lammatory Index (E-DII) score and severe nonalcoholic fatty liver disease (NAFLD) in middle-age and older adults. This prospective cohort study included 171,544 participants from the UK Biobank. The E-DII score was determined using 18 food parameters and classified into 3 categories: (i) very/moderately anti-inf lammatory diet (E-DII < − 1), (ii) neutral diet (E-DII ≥ − 1 to ≤ 1), and (iii) very/moderately proinf lammatory diet (E-DII > 1). Association between the E-DII score and the incidence of severe NAFLD was evaluated using Cox proportional hazard models. It was found that 1489 participants developed severe NAFLD over a median follow-up of 10.2 years. Patients in the very/moderately proinf lammatory diet category were at 1.54 times higher risk of severe NAFLD compared with those in the very/moderately anti-inf lammatory diet group. It was identified that a higher E-DII score was linked with a higher NAFLD risk. These findings suggest that proinf lammatory diets were associated with a higher risk of severe NAFLD, independent of confounders such as metabolic syndrome components (ie, central obesity, diabetes, hypertension, low level of high-density lipoprotein, and high triglyceride). Source: Petermann-Rocha F, et al. BMC Med. 2023;21:123. A recent study published in the Journal of Alzheimer’s Disease investigated the correlation between the degree of similarity in brain atrophy patterns in obesity and Alzheimer’s disease (AD). The study was performed using samples from 1300 individuals from 4 groups: (i) patients with AD, (ii) healthy controls (HCs), (iii) obese but otherwise healthy individuals, and (iv) lean patients with AD. It was found that obesity and AD affected gray matter cortical thinning in similar ways. The thinning in the right temporoparietal cortex and the left prefrontal cortex was similar in both AD and obesity groups, but not with amyloid-β or tau distribution, indicating obesity as a significant risk factor of AD. Researchers postulated that cortical thinning may be a sign of neurodegeneration. The study results also highlight the importance of reducing excess body weight in obese individuals to decrease the subsequent risk of neurodegeneration and AD. Source: Morys F, et al. J Alzheimer’s Dis. 2023;91(3):1059–1071. Similarity in Neurodegeneration Pattern Between Obese Individuals and Patients With Alzheimer's Disease Association Between Inflammatory Diet Index and Severe Nonalcoholic Fatty Liver Disease
RkJQdWJsaXNoZXIy MjAwNDg=