13 Evecare • Vol 11 • No. 2 • Sep–Dec 2023 Interview Extrauterine Manifestations of Polycystic Ovary Syndrome Doctor, women with polycystic ovary syndrome (PCOS) are often diagnosed with one or the other metabolic disease. What are the most common metabolic diseases associated with PCOS? That is correct. Various unhealthy lifestyle factors lead to the development of heterogeneous metabolic diseases in women with PCOS. Metabolic manifestations such as insulin resistance (IR), obesity, dyslipidemia, and hyperandrogenism are frequently diagnosed in women with PCOS. Doctor, how is insulin sensitivity affected in women with PCOS? PCOS can trigger IR in the peripheral tissues of the skeletal muscle and adipose tissue and affect the functioning of the insulin receptors, thereby impairing glucose metabolism. Most women with PCOS who have impaired glucose tolerance are at a higher risk of developing type 2 diabetes mellitus. Doctor, are there any hepatic manifestations of PCOS? Yes, PCOS can also trigger liver diseases. PCOS affects the normal functioning of the mitochondria, leading to oxidative stress. Persistent oxidative stress can aggravate hyperandrogenism, IR, and hepatic lipid accumulation, which can contribute to hepatic steatosis and nonalcoholic fatty liver disease in women with PCOS. Doctor, could you suggest a few ways to simultaneously manage metabolic diseases and PCOS? Lifestyle modification through diet recalibration and regular physical activity are considered as effective nonpharmacologic approaches to manage metabolic diseases and PCOS. Adopting a low-carbohydrate diet, or diets rich in complex carbohydrates, fiber, and monounsaturated fats is beneficial. A calorie-restricted diet is the best choice for managing IR. Doctor, do you have any therapeutic recommendations to alleviate PCOS and the associated symptoms? In addition to dietary interventions, I generally recommend Evecare forte, a nonhormonal menstrual modulator from Himalaya Wellness Company, for the effective management of PCOS. Evecare forte helps regularize endogenous hormonal status, corrects the cyclical rhythm, and reduces the number of abnormal follicles. Evecare forte improves ovulatory function and other metabolic derangements associated with IR through its insulin-sensitizing activity. Evecare forte also alleviates the symptoms of PCOS including hirsutism, hyperpigmentation, mood swings, anxiety, and depression and improves fertility. Dr Veena G Shinde, MD, DGO Consultant Obstetrician and Gynecologist, Infertility Specialist Shinde's Medicare Hospital Pvt Ltd Mhatarpada Jai Mata Bhavani Road Before Ramesh Nagar, Amboli Andheri West Mumbai 400061, Maharashtra India We thank our field correspondents for their inputs and support. Avadesh Kumar Pathak, Regional Manager Sandeep Kumar Dinesh Kumar Chaubey, Pharma Sales Officer HimalayaWellness Company —Editor
RkJQdWJsaXNoZXIy MjAwNDg=