11 Evecare • Vol 11 • No. 2 • Sep–Dec 2023 Effect of Antimicrobial Exposure in Pregnancy on Adverse Pregnancy Outcomes and Admission Rate to the Neonatal Intensive Care Unit: A Multi-Center Cohort Study Drug Alert Events Venue-Based Conferences Event: 2024 Maternal-Fetal Imaging Advances in OB-GYN Ultrasound Date: January 12 to 14, 2024 Venue: San Antonio, TX, USA For more details, visit: https://conferenceindex.org/ ••• Event: OB/GYN Clinical and Surgical Updates: Staying Current and Ahead of the Curve 2024 Date: February 5 to 8, 2024 Venue: Napa, CA, USA For more details, visit: https://ce.mayo.edu/ ••• Event: 20th Annual Women's Health Update 2024 Date: March 21 to 23, 2024 Venue: Scottsdale, AZ, USA For more details, visit: https://ce.mayo.edu/ ••• Event: GYNEC 2024. 2nd Edition of Global Conference on Gynecology & Women’s Health Date: March 21 to 23, 2024 Venue: Singapore For more details, visit: https://gynecology. magnusconferences.com/ ••• The objective of this study was to explore the association between antimicrobial exposure during pregnancy and pregnancy outcomes. This multicentric retrospective cohort study on pregnant patients (N = 370) was conducted in 22 tertiary care hospitals in China. Adverse pregnancy outcomes and admission rate of neonates to the neonatal intensive care unit (NICU) were considered. The effect of antimicrobial exposure on the outcomes was assessed using a multivariate logistic regression model. The use of first-generation cephalosporins during pregnancy was associated with a significantly higher risk of adverse pregnancy outcomes (P = .007) and admission of the neonates to the NICU (P = .009), compared with the use of third-generation cephalosporins, after adjusting for gestational age at exposure to the antimicrobial agents, cesarean section, and antimicrobial dose. Similarly, higher risks of adverse pregnancy outcomes and NICU admission rate were observed among women who were on first-generation cephalosporins compared with mothers with no antimicrobial use. The use of both first- and third-generation cephalosporins was associated with an increased risk of adverse pregnancy and neonatal outcomes. In addition, first-generation cephalosporins were associated with an increased risk of adverse pregnancy and neonatal outcomes compared with third-generation cephalosporins. Source: Li Y, et al. Infect Drug Resist. 2023;16:2441–2451.
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