Sep–Dec 2023 • Vol LXII • No. 5 9 Effect of Uncontrolled Type 2 Diabetes Mellitus on Male Sexual Hormone Function and Sperm Quality Type 2 diabetes mellitus (T2DM) is one of the most widespread health care issues in the world. The increasing incidence of T2DM in men of reproductive age has led researchers to continue to determine the role of T2DM in deranging male fertility status. Recently, a cross-sectional study was undertaken to establish the relationship between T2DM, sperm parameters (ie, sperm count, semen volume, motility, and morphology), and sex hormone levels in men. This study enrolled 25 healthy men (control group: aged 30–59 y) and 35 diabetic men (group 2: aged 30–45 y and group 3: aged 36–59 y). Semen samples were collected for analysis, and blood samples were collected for the analyses of hematologic parameters and levels of sex hormones (follicle-stimulating hormone [FSH], luteinizing hormone [LH], total testosterone [TT], estradiol [E2], and prolactin [PRL] hormone). Upon evaluation, it was observed that the levels of FSH, LH, and TT were significantly lower, and the levels of E2 and PRL were significantly higher in diabetic patient groups 2 and 3 compared with the control group. A significant low sperm concentration and a higher concentration of sluggish and dead sperms as well as abnormal sperms were found in diabetic patient groups 2 and 3 compared with the control group. Thus, the study demonstrated that men with T2DM are susceptible to sexual hormone dysfunction and diminished sperm quality. Significant health consequences from T2DM can be reduced by routine monitoring and regulation of blood glucose levels. Source: Ali BR, et al. J Med Life. 2022;15(12):1507–1510. Role of Metabolic Syndrome Components in Predicting Erectile Dysfunction in Men With Type 2 Diabetes Mellitus Erectile dysfunction (ED) is an underreported complication that arises in the presence of type 2 diabetes mellitus (T2DM). Reports suggest that ED is 3-fold highly prevalent in patients with T2DM. Furthermore, metabolic syndrome components such as hypertension, central obesity, and levels of abnormal triglyceride and high-density lipoprotein (HDL) are also hypothesized to affect erectile function in men with T2DM. Recently, the Diabetic Complications and Erectile Dysfunction study evaluated the effect of metabolic syndrome components on the erectile function in patients with T2DM. This cross-sectional study enrolled 45 patients with T2DM (aged > 18 y) with no history of alcohol or substance abuse and acute illnesses. Patients were evaluated for the presence of metabolic comorbidities. Laboratory analyses for fasting plasma glucose, glycated hemoglobin, liver and kidney functions, HDL, total cholesterol, triglycerides, and albuminuria were also performed. Sexual function was assessed using the international index of erectile function (IIEF) questionnaire. Based on questionnaire scores, ED was diagnosed in 87.2% of the patients with metabolic syndrome. Of which, 84.6% showed abnormal levels of HDL. These patients with T2DM with abnormal HDL levels showed a significant association with the presence of ED and IIEF score. Thus, the study showed that abnormal HDL levels can be considered a significant predictor of ED in patients with T2DM. Managing glycemic levels and avoiding the occurrence of metabolic derangements may help in the prevention of ED in patients with T2DM. Source: Katsimardou A, et al. Metabolites. 2023;13(5):617. Himcolin® (GEL) Strengthens erectile power and improves sexual potency Confido® (TABLET) Restores his confidence Tentex forte® (TABLET) Enhances desire and improves performance For low libido... In various ejaculatory disorders... In erectile dysfunction...
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