8 • Sep–Dec 2023 • Vol LXII • No. 5 The Latest in Medicine Effect of High-Fiber Diet in Improving Glucose Homeostasis in Patients With Type 2 Diabetes Mellitus Gut dysbiosis is a frequent complaint in patients with type 2 diabetes mellitus (T2DM). Various research findings reveal that consumption of functional foods could enhance the insulin sensitivity and antioxidant and anti-inflammatory properties in patients with T2DM. Fiber-rich diets provide sufficient carbohydrates for the gut microbiota to ferment and ensure regulation of metabolic functions via microbial metabolites. Thus, high-fiber diets could help ameliorate metabolic syndromes such as T2DM. Recently, a study was conducted to analyze changes in gut microbiota, metabolic function, emotional mood, and glucose homeostasis of patients with T2DM after the consumption of a high-fiber diet. This randomized, open-label, parallel-group clinical study enrolled patients with T2DM with plasma HbA1c levels ranging from 6.5% to 12%. The patients received either acarbose (100 mg; 3 times/day) + common diet for T2DM (control group) or acarbose (100 mg; 3 times/day) + high-fiber diet (treatment group), for 8 weeks. At the end of the treatment period, anthropometric parameters, serum and fecal samples, and questionnaires to record Hamilton anxiety scale and Hamilton depression scale were evaluated. Upon analyses, it was found that a high-fiber diet significantly improved the status of glucose homeostasis, beneficial gut microbes, systemic inflammatory response, and psychiatric comorbidities. Thus, the study demonstrated that consumption of a high amount of fermentable fiber in the diet can provide effective metabolic benefits for patients with T2DM. Source: Chen L, et al. Front Cell Infect Microbiol. 2023;13:1069954. Role of Micro- and Macronutrients in Improving Glucose Homeostasis in Patients With Type 2 Diabetes Mellitus Nutrition plays a crucial role in the development and progression of type 2 diabetes mellitus (T2DM). Mounting scientific studies emphasize that hypercaloric diet (ie, diet high in carbohydrates and fatty acids) can induce epigenetic changes among patients with T2DM, and that balanced diets such as the Mediterranean diet could help prevent T2DM complications. Recently, a population-based study was undertaken to determine nutritional components associated with T2DM development and their effect on glucose homeostasis. This study was a prospective cross-sectional survey on the nutritional dietary intake in a representative sample of a Northern East Tunisian population. Based on the data regarding demographics, anthropometrics, dietary intake, lifestyle, and glycated hemoglobin (HbA1c) levels, the participants were divided into diabetic (HbA1c: ≥ 6.5%), nondiabetic (HbA1c: < 5.7%), and prediabetic (HbA1c: 5.7%–6.49%) groups. Variance analyses showed that the diabetic and prediabetic groups consumed a high amount of hypercaloric diet and less amounts of vitamins (eg, riboflavin, niacin, vitamin B5, and vitamin D), minerals (eg, magnesium, calcium, zinc, phosphorus, potassium, and total iron), cholesterol, and water. Hypercaloric diet and insufficient intake of vitamins and minerals interfere with the insulin secretion pathway, alter glucose tolerance, increase oxidative stress and inflammation, and decrease immune responses. Thus, the study confirmed that the regulation of glucose homeostasis in patients with T2DM is strongly linked to the quantity and quality of dietary intake. Source: Kheriji N, et al. Nutrients. 2022;14(10):2132. ® Researched Nutritional Supplement for Diabetics In the nutritional management of diabetes... FOOD FOR SPECIAL DIETARY USE – For diabetic and prediabetic individuals. Pregnant, nursing and lactating women or infants, children under 5 years, adolescents and the elderly should consult a health care professional before use. NOT FOR MEDICINAL USE. Not for parenteral use. Do not exceed the recommended daily usage. Allergen Statement: Contains milk and soy ingredients. Manufactured in a facility handling nuts and cereals. To be used under the medical advice of a health care professional, as par t of a diabetes management regimen for adults, which includes physical activity and a healthy diet. Keep out of the reach of children. Delicious Milk Masala and Vanilla Flavors
RkJQdWJsaXNoZXIy MjAwNDg=