2 Influence of Nutritional Insufficiency on Menstrual Irregularities A woman's reproductive health can be ascertained through the regularity of the menstruation pattern. Irregular menstruation is an indicator of a dysfunctional sex hormone profile and disorders of the reproductive organs. Abnormalities in the menstrual cycle can range from dysfunctional bleeding patterns such as amenorrhea, dysmenorrhea, menorrhagia, and hypomenorrhea to ovulatory disorders. Ovulatory dysfunction in women is mostly a result of temporary or chronic disturbances in the hypothalamic–pituitary–ovarian axis. Internal factors (eg, anemia and hormonal imbalance) and external factors (eg, diet, physical activity, stress, smoking, alcohol intake, and medications) can influence the onset of menstrual irregularities. Limited food intake, poor dietary choices, insufficient nutritional intake, and psychologic stress can lead to Aim To evaluate the efficacy of Evecare capsules in relieving the symptoms of dysfunctional uterine bleeding (DUB) Materials and Methods This study enrolled 70 women (age, 20–45 y) with a history of DUB. Their medical history was recorded, and they were subjected to general physical and pelvic examinations. They were also subjected to extensive laboratory investigations including a complete hemogram coagulation profile to establish the degree of blood loss, for evidence of iron-deficiency anemia (IDA), and to exclude any bleeding disorder(s). At entry, 18 women had a normal duration of menstruation, but increased menstrual flow, 21 women had normal flow but increased duration, and 31 women had increased flow and increased duration. All the women were given Evecare capsules at a dosage of 2 capsules, BID, for 3 months. They were evaluated for the duration of menstruation and amount of blood loss, degree of IDA, and general condition during and at the end of the treatment period. Results All the 70 women completed the study. The results showed that the duration of menstruation and the amount of menstrual flow started to normalize by the end of the second month of the treatment with Evecare capsules. By the end of 3 months, 90% of the women had a normal duration of menstruation (Table 1). After the treatment, the amount of menstrual flow was normalized in 59 women. Table 2 presents data about the effect of Evecare capsules on the amount of menstrual flow. A total of 57 women experienced complete relief from the symptoms of DUB after Capsules in the Management of Dysfunctional Uterine Bleeding obesity, underweight, diabetes, and hypertension. Poor eating habits can affect the secretion of Sources: Park YJ, et al. Int J Environ Res Public Health. 2021;18(1):233. Gupta DS, et al. J Evolution Med Dent Sci. 2021;10(15):1048–1053. reproductive hormones such as estrogen and progesterone that regulate menstrual cycles. Results from a Danish study comprising 18- to 40-year-old women confirmed that women with binge eating habits showed a higher frequency of amenorrhea or oligomenorrhea than women with no binge eating habits. An imbalanced diet or nutritional insufficiency can lead to painful menstruation. Consumption of a healthy diet with the right balance of macronutrients and micronutrients supports a healthy and normal menstrual cycle. The menstrual cycle is termed as Rutuchakra in Ayurveda. The word “chakra” signifies its regular onset at regular intervals, just like a cycle. All 3 doshas (Vata, Pitta, and Kapha) have an influence at different stages of the menstrual cycle, and any impairment in these doshas leads to Menstrual Irregularities: An Ayurvedic Perspective menstrual irregularities (MIs). Vitiation of doshas and tissues (rasa and rakta) and blockage of channels of the female reproductive system (artavavaha srotas) are major causes of MIs. Abnormalities in the menstrual flow can be of 2 types—increased and decreased menstrual flow. Based on the dominance of the vitiated dosha (which results in altered color, smell, frequency, and consistency of menstrual fluid), MIs are of 8 types. The other MIs mentioned in Ayurveda are amenorrhea (nashtartava), oligomenorrhea (artavakshaya), metrorrhagia (asragdara), and dysmenorrhea (kashtartava). Table 1. The Effect of Treatment With Evecare Capsules on the Duration of Menstruation in Women With DUB Duration of Menstruation, d No. of Women (N = 70), n (%) Before Treatment After Treatment 3–4 (Normal) 18a (26) 63 (90) (6a [9]) 5–8 36 (51) 3 (4) > 8 16 (23) 4 (6) Total 70 (100) 70 (100) aWomen who had normal duration of menstruation but severe menstrual flow. DUB, dysfunctional uterine bleeding. Table 2. The Effect of Treatment With Evecare Capsules on the Amount of Menstrual Flow in Women With DUB No. of Sanitary Pads Changed Per Day No. of Women (N = 70), n (%) Before Treatment After Treatment 3–4 (Normal) 21a (30) 59 (84) (2a [3]) 4–5 30 (43) 7 (10) > 5 19 (27) 4 (6) Total 70 (100) 70 (100) aWomen who had a normal menstrual flow but prolonged duration of menstruation. DUB, dysfunctional uterine bleeding. Evecare is recommended for the management of uterine disorders. Evecare regularizes endogenous hormonal secretion, corrects cyclical rhythm, and offers relief from the symptoms of dysfunctional uterine bleeding (DUB) and premenstrual syndrome. Evecare enhances endometrial receptivity and assists full-term pregnancy. Evecare has a regularizing influence on the menstrual cycle by virtue of its uterine-stimulant action. Evecare’s stimulatory effect on the ovarian tissue helps regularize endogenous hormonal secretion, helps enhance the repair of the endometrium, and thus, helps control abnormal uterine bleeding. Pharmacologic Actions z z Phytoestrogenic action z z Gonadotropin agonist action z z Antihemorrhagic action z z Antimicrobial action z z Anti-inflammatory and analgesic actions z z Antispasmodic action z z Antioxidant action z z Adaptogenic action Indications z z Menstrual irregularities – DUB: Menorrhagia, metrorrhagia – Oligomenorrhea z z Dysmenorrhea z z Premenstrual syndrome (PMS) z z Polycystic ovarian syndrome (PCOS) z z Assisted conception s with tagline Curved h the treatment with Evecare capsules. There were no adverse effects reported during the study. Discussion and Conclusion The phytoestrogens present in the herbs of Evecare capsules produce a healing effect on the endometrium. The herbs also exhibit a styptic action, which helps limit the bleeding by inducing vasoconstriction of the microvessels that supply blood to the endometrium and by increasing the myometrial contractility to produce hemostasis. The results of this study show that Evecare capsules are effective in relieving the symptoms of DUB. An excerpt of the clinical study conducted by Prasad Nevrekar et al published in the journal Obstetrics & Gynaecology Communications is featured here. Brand names with tagline Open type Curved Builds the body’s own defense mechanism Evecare® Ensures complete uterine care (CAPSULE, SYRUP) Septilin® (SYRUP, TABLET)
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